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<p>The understanding of autoinflammatory disorders, which are caused by the dysregulated activation of the innate immune system, has improved with the discovery of new diseases and the expansion of phenotypes. Inflammation can be controlled using immunosuppressive drugs, biological agents, and molecular-targeted therapies. However, some cases remain refractory to treatment, and certain patients experience side effects associated with the long-term use of corticosteroids. Recently, allogeneic hematopoietic cell transplantation (HCT) was reported to improve symptoms in refractory cases. Based on the previous reports, in this review, we discuss the potential of HCT in the treatment of autoinflammatory disorders.</p>

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Allogeneic hematopoietic cell transplantation for autoinflammatory disorders

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月11日

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  • Hirokazu Kanegane,
  • Satoshi Miyamoto,
  • Takahiro Kamiya,
  • Hidenori Ohnishi,
  • Ryuta Nishikomori,
  • Andrew R. Gennery,
  • Takehiko Mori

摘要

The understanding of autoinflammatory disorders, which are caused by the dysregulated activation of the innate immune system, has improved with the discovery of new diseases and the expansion of phenotypes. Inflammation can be controlled using immunosuppressive drugs, biological agents, and molecular-targeted therapies. However, some cases remain refractory to treatment, and certain patients experience side effects associated with the long-term use of corticosteroids. Recently, allogeneic hematopoietic cell transplantation (HCT) was reported to improve symptoms in refractory cases. Based on the previous reports, in this review, we discuss the potential of HCT in the treatment of autoinflammatory disorders.