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<p>A 15-year-old boy with congenital mitochondrial disease was diagnosed with acute promyelocytic leukemia. He was treated with all-trans retinoic acid, and his anthracycline dose was reduced in response to his underlying condition. He successfully achieved molecular remission and maintained this state for 4&#xa0;years. In vitro drug sensitivity testing in peripheral mononuclear cells suggests that samples from patients in remission show higher sensitivity to various anticancer drugs than samples from healthy volunteers. Reduced-dose chemotherapy could be a valid treatment option for patients with mitochondrial diseases because exposure to elevated oxidative stress may contribute to increased drug sensitivity in these patients.</p>

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A case of acute promyelocytic leukemia complicated by mitochondrial disease

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月1日

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  • Yukari Sakurai,
  • Masakatsu Yanagimachi,
  • Mieko Ito,
  • Ayana Hirose,
  • Naoyuki Miyagawa,
  • Dai Keino,
  • Tomoko Yokosuka,
  • Fuminori Iwasaki,
  • Satoshi Hamanoue,
  • Masae Shiomi,
  • Shoko Goto,
  • Tomohide Goto,
  • Hiroaki Goto

摘要

A 15-year-old boy with congenital mitochondrial disease was diagnosed with acute promyelocytic leukemia. He was treated with all-trans retinoic acid, and his anthracycline dose was reduced in response to his underlying condition. He successfully achieved molecular remission and maintained this state for 4 years. In vitro drug sensitivity testing in peripheral mononuclear cells suggests that samples from patients in remission show higher sensitivity to various anticancer drugs than samples from healthy volunteers. Reduced-dose chemotherapy could be a valid treatment option for patients with mitochondrial diseases because exposure to elevated oxidative stress may contribute to increased drug sensitivity in these patients.