<p>The post-COVID syndrome (PCS) is defined as persisting symptoms (&gt;12 weeks) following an infection with severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), which cannot be explained by any other disease. The PCS is a multiorgan syndrome of unknown etiology. Whether these symptoms are directly attributable to the SARS-CoV‑2 infection or due to secondary factors, i.e., additional viral or nonviral mechanisms including psychosomatic disorders, remains to be elucidated. Cardiac symptoms include dyspnea, chest pain and palpitations. Typically, there are no conspicuous findings in the routine cardiological assessment. Perimyocarditis in particular should be considered if elevation of N‑terminal pro-brain natriuretic peptide (NT-proBNP) and troponin are detected, including pathologies in cardiac magnetic resonance imaging (MRI). Symptoms such as delayed fatigue after exertion, the so-called post-exertional malaise (PEM) or the postural tachycardia syndrome (POTS) also occur but are relatively unspecific. So far, no specific biomarkers are available for the detection of the PCS. The multifactorial underlying pathomechanisms as well as the variation in symptoms over time complicate a precise diagnosis: however, clinical findings point to a systemic endothelial dysfunction and a dysregulation of the immune system that may contribute to metabolic, endocrinological and neurocognitive disorders. Patients with PCS can benefit from controlled physical activity. A specific pharmacological treatment for patients with PCS is lacking.</p>