Scholarlink

<p>Developing and validating a stable, environmentally friendly technology to quantify the amounts of nicotinamide and cocarboxylase, in addition to adenosine triphosphate, in bulk and in dosage form for freeze-dried injections through micro-scale sample preparation is the main goal of the intended study. The green mobile phase used was 0.025 M potassium dihydrogen phosphate at pH 6.0. The adenosine triphosphate concentration range was 20.24–202.4 µg/mL, the cocarboxylase concentration range was 101.04–1010.4 µg/mL, and the nicotinamide concentration range was 40.24–402.4 µg/mL with correlation coefficient <i>R</i><sup>2</sup> ≥ 0.999. The final AES of 84, CACI grade of 74, AGSA grade of 77.78, score of AGREEprep = 0.76, score of MoGAPI = 76, score of BAGI = 82.5, and whiteness of 85.8 all showed how sustainable the system was. ICH validation parameters, cost-effectiveness, and environmental friendliness, in contrast with the published techniques as stated below, are some of the distinctive qualities of the approach being offered.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A Green Simultaneous Stability Indicating Method for a Coenzyme and Vitamins in Parenteral Medications Through a Micro-Scale Sample Preparation

  • 期刊论文

  • 发表日期：

    2026年4月1日

查看全文
  • Jin-Kui Ma,
  • Xiao-Yang Chen,
  • Yu-Tong Lin,
  • Ahmed Sobhy Darwish,
  • Ayman A. Gouda,
  • Ragaa El Sheikh,
  • Xiang Li

摘要

Developing and validating a stable, environmentally friendly technology to quantify the amounts of nicotinamide and cocarboxylase, in addition to adenosine triphosphate, in bulk and in dosage form for freeze-dried injections through micro-scale sample preparation is the main goal of the intended study. The green mobile phase used was 0.025 M potassium dihydrogen phosphate at pH 6.0. The adenosine triphosphate concentration range was 20.24–202.4 µg/mL, the cocarboxylase concentration range was 101.04–1010.4 µg/mL, and the nicotinamide concentration range was 40.24–402.4 µg/mL with correlation coefficient R2 ≥ 0.999. The final AES of 84, CACI grade of 74, AGSA grade of 77.78, score of AGREEprep = 0.76, score of MoGAPI = 76, score of BAGI = 82.5, and whiteness of 85.8 all showed how sustainable the system was. ICH validation parameters, cost-effectiveness, and environmental friendliness, in contrast with the published techniques as stated below, are some of the distinctive qualities of the approach being offered.

Graphical Abstract