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<p>Tetracycline (TC) and chloramphenicol (CAP) are widely used antibiotics, but their residues in food pose significant risks to human health (e.g., potential toxicity) and promote the development of antibiotic resistance. Consequently, many countries have imposed strict regulations or even complete bans on their use in food-producing animals. Thus, the development of efficient, sensitive, and on-site detection methods for TC and CAP residues is of great practical significance for ensuring food safety. Herein, we report the synthesis of nitrogen and silicon co-doped carbon dots (N,Si-CDs) via a one-step hydrothermal method using N-acetyl-L-cysteine and 3-aminopropyltriethoxysilane (APTES) as precursors. The as-synthesized N,Si-CDs exhibit excellent hydrophilicity and stable fluorescence properties.This method breaks through the limitation of traditional probes that can only detect a single substance, and achieves high sensitivity detection of TC and CAP respectively, with linear ranges of 10–30&#xa0;μM (TC) and 10–40&#xa0;μM (CAP), respectively, and detection limits as low as 0.45&#xa0;μM (TC) and 0.54&#xa0;μM (CAP). We developed a visual detection system using the ColorPicker application to quantify antibiotic concentration through RGB signals (blue channel intensity) and achieve rapid on-site screening. This probe has good selectivity and resists interference, successfully detecting TC and CAP in real food samples, showing good recovery rates and practical applicability.</p> Graphical Abstract <p>In this paper, nitrogen- and silicon-codoped carbon quantum dots (N,Si-CDs) were synthesized via a one-step hydrothermal method which exhibited excellent recognition ability for tetracycline (TC) and chloramphenicol (CAP), and were successfully applied to the detection of TC and CAP in different foods.</p> <p></p>

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Development of a High-Performance Fluorescent Probe for Food Safety: N,Si-CDs for Detecting Tetracycline and Chloramphenicol

  • 期刊论文

  • 发表日期：

    2026年2月6日

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  • Dilong Hong,
  • Fanshu Zhao,
  • Yuliang Jiang

摘要

Tetracycline (TC) and chloramphenicol (CAP) are widely used antibiotics, but their residues in food pose significant risks to human health (e.g., potential toxicity) and promote the development of antibiotic resistance. Consequently, many countries have imposed strict regulations or even complete bans on their use in food-producing animals. Thus, the development of efficient, sensitive, and on-site detection methods for TC and CAP residues is of great practical significance for ensuring food safety. Herein, we report the synthesis of nitrogen and silicon co-doped carbon dots (N,Si-CDs) via a one-step hydrothermal method using N-acetyl-L-cysteine and 3-aminopropyltriethoxysilane (APTES) as precursors. The as-synthesized N,Si-CDs exhibit excellent hydrophilicity and stable fluorescence properties.This method breaks through the limitation of traditional probes that can only detect a single substance, and achieves high sensitivity detection of TC and CAP respectively, with linear ranges of 10–30 μM (TC) and 10–40 μM (CAP), respectively, and detection limits as low as 0.45 μM (TC) and 0.54 μM (CAP). We developed a visual detection system using the ColorPicker application to quantify antibiotic concentration through RGB signals (blue channel intensity) and achieve rapid on-site screening. This probe has good selectivity and resists interference, successfully detecting TC and CAP in real food samples, showing good recovery rates and practical applicability.

Graphical Abstract

In this paper, nitrogen- and silicon-codoped carbon quantum dots (N,Si-CDs) were synthesized via a one-step hydrothermal method which exhibited excellent recognition ability for tetracycline (TC) and chloramphenicol (CAP), and were successfully applied to the detection of TC and CAP in different foods.