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<p>Molecularly imprinted polymer (MIP) has been intensively investigated as a solid phase extraction material for water treatment in environmental engineering, as well as a pre-concentration media for chromatographic analysis of trace analytes in complex samples. The selective binding capability of MIPs toward target template molecules has also been exploited in the development of chemical sensors for the selective detection of analytes in intricate sample environments. In this paper, we present the development of a novel optical fiber chemical sensor for the detection of chlorogenic acid (CGA), based on the integration of a MIP with evanescent wave fiber optic UV/Vis absorption spectrometry. A chitosan-based MIP, synthesized using CGA as the template molecule, was applied as a membrane coating on the surface of a bent optical fiber core. The MIP selectively binds and concentrates CGA into the membrane from a sample solution, which was detected by monitoring variations in the light intensity transmitted through the optical fiber probe. The sensor exhibited high selectivity toward CGA and was capable of detecting the target analyte in complex sample matrices. Owing to the concentration effect imparted by the MIP membrane, the sensor demonstrated high sensitivity, achieving a detection limit of 6.7&#xa0;ng/mL. The sensor’s performance was validated through the analysis of CGA extracted from powdered green coffee beans and a commercial CGA dietary supplement. The results obtained were in close agreement with those from conventional optical absorption spectrometric analysis, confirming the reliability and accuracy of the proposed sensing approach. The relative standard deviation for analyzing CGA in test sample solutions in concentration range from 3.2 to 5.7&#xa0;µg/mL was from 2.5% to 3.5%.</p>

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An Optical Fiber Chemical Sensor Using a Molecularly Imprinted Polymer Membrane as a Transducer for Analyzing Chlorogenic Acid in Coffee Products

  • 期刊论文

  • 发表日期：

    2025年12月3日

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  • Ricardo Mendoza,
  • Shiquan Tao

摘要

Molecularly imprinted polymer (MIP) has been intensively investigated as a solid phase extraction material for water treatment in environmental engineering, as well as a pre-concentration media for chromatographic analysis of trace analytes in complex samples. The selective binding capability of MIPs toward target template molecules has also been exploited in the development of chemical sensors for the selective detection of analytes in intricate sample environments. In this paper, we present the development of a novel optical fiber chemical sensor for the detection of chlorogenic acid (CGA), based on the integration of a MIP with evanescent wave fiber optic UV/Vis absorption spectrometry. A chitosan-based MIP, synthesized using CGA as the template molecule, was applied as a membrane coating on the surface of a bent optical fiber core. The MIP selectively binds and concentrates CGA into the membrane from a sample solution, which was detected by monitoring variations in the light intensity transmitted through the optical fiber probe. The sensor exhibited high selectivity toward CGA and was capable of detecting the target analyte in complex sample matrices. Owing to the concentration effect imparted by the MIP membrane, the sensor demonstrated high sensitivity, achieving a detection limit of 6.7 ng/mL. The sensor’s performance was validated through the analysis of CGA extracted from powdered green coffee beans and a commercial CGA dietary supplement. The results obtained were in close agreement with those from conventional optical absorption spectrometric analysis, confirming the reliability and accuracy of the proposed sensing approach. The relative standard deviation for analyzing CGA in test sample solutions in concentration range from 3.2 to 5.7 µg/mL was from 2.5% to 3.5%.