<p>The widespread use of veterinary drugs in livestock production, while beneficial for disease prevention and growth promotion, leads to hazardous residues in animal-derived foods that significantly endanger human health. This review comprehensively examines nanozyme-based detection technologies as a transformative solution, highlighting their superior sensitivity, rapid response, operational simplicity, and cost-effectiveness compared to conventional methods. We systematically analyze the following: (1) major veterinary drug categories and associated health risks; (2) fundamental principles and practical applications of diverse nanozyme sensors; and (3) critical evaluation of current detection platforms for animal-derived foods. And several pivotal performance-enhancement strategies are emphasized: dual-mode detection system development, enzyme cascade catalytic network design, precise nanozyme activity regulation, specialized recognition element incorporation, and innovative sensing platform construction. The review concludes with forward-looking insights on emerging trends and practical recommendations, serving as a valuable reference for advancing next-generation veterinary drug monitoring technologies in food safety applications.</p>

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Recent Advances in Nanozyme-Based Sensors for the Detection of Veterinary Drug Residues in Food

  • Hongyu Shen,
  • Yi Fang,
  • Xiuxiu Li,
  • Dingyu Hu,
  • Jinxin Cheng

摘要

The widespread use of veterinary drugs in livestock production, while beneficial for disease prevention and growth promotion, leads to hazardous residues in animal-derived foods that significantly endanger human health. This review comprehensively examines nanozyme-based detection technologies as a transformative solution, highlighting their superior sensitivity, rapid response, operational simplicity, and cost-effectiveness compared to conventional methods. We systematically analyze the following: (1) major veterinary drug categories and associated health risks; (2) fundamental principles and practical applications of diverse nanozyme sensors; and (3) critical evaluation of current detection platforms for animal-derived foods. And several pivotal performance-enhancement strategies are emphasized: dual-mode detection system development, enzyme cascade catalytic network design, precise nanozyme activity regulation, specialized recognition element incorporation, and innovative sensing platform construction. The review concludes with forward-looking insights on emerging trends and practical recommendations, serving as a valuable reference for advancing next-generation veterinary drug monitoring technologies in food safety applications.