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<p>Sulfadiazine, an antibiotic belonging to the sulfonamide class, is commonly utilized in aquaculture and animal farming because of its affordability. However, the misuse of this antibiotic can lead to harmful health effects in humans, necessitating effective methods for detecting its residues in food products. Despite advancements in residue detection, challenges remain, particularly in dealing with interference from complex food matrices like milk. In this research, we synthesized F-modified Ag-TpBD-COF materials to serve as substrates for surface-enhanced Raman spectroscopy (SERS), aiming to detect sulfadiazine residues in milk. The Covalent organic frameworks (COF) materials, serving as ligands, effectively minimized interference, enhancing the method’s accuracy. The method demonstrated excellent sensitivity with a linear detection range of 1–50 μg/L and a limit of detection (LOD) was 0.69 μg/L. These findings highlight the potential of the novel Ag-TpBD-COF SERS substrate for high-sensitivity and reliable food safety monitoring.</p>

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Sulfadiazine Detection in Milk Using F−-modified Ag-TpBD-COF as SERS Substrate

  • 期刊论文

  • 发表日期：

    2025年7月13日

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  • Yunpeng Shang,
  • Anqi Hu,
  • Chaoqun Ma,
  • Jiao Gu,
  • Yamin Wu,
  • Chun Zhu,
  • Lei Li,
  • Hui Gao,
  • Taiqun Yang,
  • Guoqing Chen

摘要

Sulfadiazine, an antibiotic belonging to the sulfonamide class, is commonly utilized in aquaculture and animal farming because of its affordability. However, the misuse of this antibiotic can lead to harmful health effects in humans, necessitating effective methods for detecting its residues in food products. Despite advancements in residue detection, challenges remain, particularly in dealing with interference from complex food matrices like milk. In this research, we synthesized F-modified Ag-TpBD-COF materials to serve as substrates for surface-enhanced Raman spectroscopy (SERS), aiming to detect sulfadiazine residues in milk. The Covalent organic frameworks (COF) materials, serving as ligands, effectively minimized interference, enhancing the method’s accuracy. The method demonstrated excellent sensitivity with a linear detection range of 1–50 μg/L and a limit of detection (LOD) was 0.69 μg/L. These findings highlight the potential of the novel Ag-TpBD-COF SERS substrate for high-sensitivity and reliable food safety monitoring.