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<p>The presence of chloramphenicol (CAP) residues in animal-derived foods has the potential to accumulate in the human body during metabolism, which can result in adverse effects on human health. Herein, a novel ultrasensitive detection platform based on liquid exfoliated graphene (LEG)/Ti<sub>3</sub>C<sub>2</sub> MXene nanocomposites modified indium tin oxide (ITO) electrode (LEG/Ti<sub>3</sub>C<sub>2</sub> MXene/ITO), is proposed for the detection of CAP. The embedding of LEG into Ti<sub>3</sub>C<sub>2</sub> MXene can suppress the aggregation of Ti<sub>3</sub>C<sub>2</sub> MXene flakes, which has been proven to be an effective method for improving sensing performance due to its advantages of higher specific surface area and electron transfer efficiency. The CAP-specific aptamer is immobilized on LEG/Ti<sub>3</sub>C<sub>2</sub> MXene/ITO through π-π adsorption as the bio-recognition element. Differential pulse voltammograms are utilized to analyze the changes in peak current of the modified electrode before and after the interaction between the immobilized aptamer and CAP, achieving quantitative measurement of CAP. The prepared aptamer/LEG/Ti<sub>3</sub>C<sub>2</sub> MXene/ITO sensor has allowed the linear concentration range of CAP from 0.001&#xa0;pM to10 μM, with a limit of detection (LOD) of 0.485 fM. The sensor performs well in stability, reproducibility, and selectivity. Additionally, it is demonstrated successfully to detect CAP in the spiked samples of milk and honey.</p> Graphical Abstract <p></p>

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Liquid Exfoliated Graphene/Ti3C2 MXene Composite Based Aptasensor for Ultrasensitive Electrochemical Detection of Chloramphenicol in Milk and Honey

  • 期刊论文

  • 发表日期：

    2025年7月10日

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  • Panpan Dong,
  • Fang Li,
  • Zijian Wu,
  • Lu Xue,
  • Mingming Luo,
  • Yijun Tan,
  • Haitao Li,
  • Xu Yang

摘要

The presence of chloramphenicol (CAP) residues in animal-derived foods has the potential to accumulate in the human body during metabolism, which can result in adverse effects on human health. Herein, a novel ultrasensitive detection platform based on liquid exfoliated graphene (LEG)/Ti3C2 MXene nanocomposites modified indium tin oxide (ITO) electrode (LEG/Ti3C2 MXene/ITO), is proposed for the detection of CAP. The embedding of LEG into Ti3C2 MXene can suppress the aggregation of Ti3C2 MXene flakes, which has been proven to be an effective method for improving sensing performance due to its advantages of higher specific surface area and electron transfer efficiency. The CAP-specific aptamer is immobilized on LEG/Ti3C2 MXene/ITO through π-π adsorption as the bio-recognition element. Differential pulse voltammograms are utilized to analyze the changes in peak current of the modified electrode before and after the interaction between the immobilized aptamer and CAP, achieving quantitative measurement of CAP. The prepared aptamer/LEG/Ti3C2 MXene/ITO sensor has allowed the linear concentration range of CAP from 0.001 pM to10 μM, with a limit of detection (LOD) of 0.485 fM. The sensor performs well in stability, reproducibility, and selectivity. Additionally, it is demonstrated successfully to detect CAP in the spiked samples of milk and honey.

Graphical Abstract