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Purpose <p>This study aims to explore the potential of <sup>18</sup>F-FDG PET/CT-derived metabolic parameters in predicting the prognosis of adults with multifocal Langerhans cell histiocytosis (LCH).</p> Methods <p>This retrospective study included adult patients with pathologically confirmed multifocal LCH who underwent baseline <sup>18</sup>F-FDG PET/CT scans at our institution and received appropriate treatment. The semi-quantitative PET/CT parameters evaluated included whole-body metabolic tumor volume (WBMTV), whole-body total lesion glycolysis (WBTLG), and maximum standardized uptake value (SUVmax). Receiver operating characteristic curve analysis was used to determine the optimal cut-off values for the metabolic parameters. Progression-free survival (PFS) analysis was performed for clinical features and PET/CT parameters using the log-rank test, Kaplan-Meier curves, and Cox proportional hazards models to identify prognostic factors for PFS.</p> Results <p>A total of 33 patients (22 male, 11 females; mean age 39 years, range 18–73 years) were included. During the follow-up period, 15 patients (45.5%) experienced disease progression or relapse. Univariate analysis revealed that age &gt; 50 years, positive risk organs, SUVmax &gt; 13, WBMTV &gt; 36.79, and WBTLG &gt; 277.22 were significantly associated with poor PFS (all <i>p</i> &lt; 0.05). In multivariate analysis, SUVmax &gt; 13 (HR = 4.521, 95% CI 1.137–17.968), WBMTV &gt; 36.79 (HR = 13.278, 95% CI 1.415–124.569), and WBTLG &gt; 277.22 (HR = 5.643, 95% CI 1.059–30.077) remained independent prognostic factors for PFS with statistical significance.</p> Conclusion <p>Baseline <sup>18</sup>F-FDG PET/CT-derived metabolic parameters may serve as promising imaging biomarkers for predicting the prognosis of adults with multifocal LCH.</p>

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Predictive value of metabolic parameters from PET/CT in adult multifocal Langerhans cell histiocytosis

  • 期刊论文

  • 发表日期：

    2026年1月31日

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  • Hui-min Shan,
  • Tao Chen,
  • Wei Fan

摘要

Purpose

This study aims to explore the potential of 18F-FDG PET/CT-derived metabolic parameters in predicting the prognosis of adults with multifocal Langerhans cell histiocytosis (LCH).

Methods

This retrospective study included adult patients with pathologically confirmed multifocal LCH who underwent baseline 18F-FDG PET/CT scans at our institution and received appropriate treatment. The semi-quantitative PET/CT parameters evaluated included whole-body metabolic tumor volume (WBMTV), whole-body total lesion glycolysis (WBTLG), and maximum standardized uptake value (SUVmax). Receiver operating characteristic curve analysis was used to determine the optimal cut-off values for the metabolic parameters. Progression-free survival (PFS) analysis was performed for clinical features and PET/CT parameters using the log-rank test, Kaplan-Meier curves, and Cox proportional hazards models to identify prognostic factors for PFS.

Results

A total of 33 patients (22 male, 11 females; mean age 39 years, range 18–73 years) were included. During the follow-up period, 15 patients (45.5%) experienced disease progression or relapse. Univariate analysis revealed that age > 50 years, positive risk organs, SUVmax > 13, WBMTV > 36.79, and WBTLG > 277.22 were significantly associated with poor PFS (all p < 0.05). In multivariate analysis, SUVmax > 13 (HR = 4.521, 95% CI 1.137–17.968), WBMTV > 36.79 (HR = 13.278, 95% CI 1.415–124.569), and WBTLG > 277.22 (HR = 5.643, 95% CI 1.059–30.077) remained independent prognostic factors for PFS with statistical significance.

Conclusion

Baseline 18F-FDG PET/CT-derived metabolic parameters may serve as promising imaging biomarkers for predicting the prognosis of adults with multifocal LCH.