Scholarlink

Background <p>This study aimed the role of volumetric and dissemination features of staging [18F]PSMA-1007 PET/CT in predicting progression‐free survival (PFS) in patients with prostate cancer (PCa) and their relationship with the main clinical data (ISUP grade groups, number of lesions, PSA).</p> Methods <p>We included 164 patients with high-risk PCa who underwent baseline [18F]PSMA-1007 PET/CT. With the help of LIFEx version 7.7, the main volumetric and dissemination PET parameters were semi-automatically extracted: PSMA-prostate tumor volume (PSMA-TV), PSMA-prostate total lesion (PSMA-TL), PSMA total TV (PSMA-TTV), PSMA total TL (PSMA-TTL) and Dmax corrected for body-surface-area (Dmax<sub>bsa</sub>). Spearman rank correlations between semiquantitative PET features and the clinical variables were analyzed. PFS estimates were plotted with the Kaplan–Meier method.</p> Results <p>A high correlation was seen between the number of lesions and both PSMA-TTL (r 0.725), and Dmaxbsa (r 0.935). A moderate correlation was registered between PSA and PSMA-TTV (r 0.333), PSMA-TTL (r 0.441), Dmax<sub>bsa</sub> (r 0.333), as well as between number of lesions and PSMA-TTV (r 0.342).</p> <p>After a median follow-up of 17&#xa0;months (range 2–45), relapse/progression happened in 17 patients (10%). PSA level, presence of distant metastases at staging, PSMA-TV, PSMA-TL, PSMA-TTL and Dmax<sub>bsa</sub> were significantly associated with PFS at univariate analysis, but only the presence of distant metastases, PSMA-TTL and Dmax<sub>bsa</sub> were confirmed to be independent prognostic factors.</p> Conclusion <p>Volumetric and dissemination features derived by staging [18F]PSMA-1007 PET/CT were significantly correlated with PSA and number of lesions. The combination of PSMA-TTL and Dmax<sub>bsa</sub> was the best predictor of PFS and may help to better stratify PCa patients.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The prognostic role of staging [18F]PSMA-1007 PET/CT volumetric and dissemination features in prostate cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月17日

查看全文
  • Domenico Albano,
  • Alessandro Temponi,
  • Francesco Bertagna,
  • Nazareno Suardi,
  • Anna Talin,
  • Marco Lorenzo Bonù,
  • Luca Triggiani

摘要

Background

This study aimed the role of volumetric and dissemination features of staging [18F]PSMA-1007 PET/CT in predicting progression‐free survival (PFS) in patients with prostate cancer (PCa) and their relationship with the main clinical data (ISUP grade groups, number of lesions, PSA).

Methods

We included 164 patients with high-risk PCa who underwent baseline [18F]PSMA-1007 PET/CT. With the help of LIFEx version 7.7, the main volumetric and dissemination PET parameters were semi-automatically extracted: PSMA-prostate tumor volume (PSMA-TV), PSMA-prostate total lesion (PSMA-TL), PSMA total TV (PSMA-TTV), PSMA total TL (PSMA-TTL) and Dmax corrected for body-surface-area (Dmaxbsa). Spearman rank correlations between semiquantitative PET features and the clinical variables were analyzed. PFS estimates were plotted with the Kaplan–Meier method.

Results

A high correlation was seen between the number of lesions and both PSMA-TTL (r 0.725), and Dmaxbsa (r 0.935). A moderate correlation was registered between PSA and PSMA-TTV (r 0.333), PSMA-TTL (r 0.441), Dmaxbsa (r 0.333), as well as between number of lesions and PSMA-TTV (r 0.342).

After a median follow-up of 17 months (range 2–45), relapse/progression happened in 17 patients (10%). PSA level, presence of distant metastases at staging, PSMA-TV, PSMA-TL, PSMA-TTL and Dmaxbsa were significantly associated with PFS at univariate analysis, but only the presence of distant metastases, PSMA-TTL and Dmaxbsa were confirmed to be independent prognostic factors.

Conclusion

Volumetric and dissemination features derived by staging [18F]PSMA-1007 PET/CT were significantly correlated with PSA and number of lesions. The combination of PSMA-TTL and Dmaxbsa was the best predictor of PFS and may help to better stratify PCa patients.