<p>Latinas are at higher risk for obesity and binge eating concerns relative to other ethnic groups. Our objectives were to cultural adapt an evidence-based healthy lifestyle manual with Latinas with overweight/obesity and symptoms of binge eating disorder and identify culturally relevant dissemination strategies. Guided by designing for dissemination and sustainability principles and community-based participatory research methods, we partnered with local community organizations serving Latinas and their families. We then conducted focus groups and interviews to understand their lived experiences with overweight/obesity and binge eating disorder and culturally adapted an evidence-based healthy lifestyle manual. Qualitative data were analyzed by the constant comparative method. Participants (<i>n</i> = 20) were on average 30 years old (SD = 9.87); 68% identified as first-generation Latina and 32% identified as second generation. Three primary themes emerged: (1) there was a lack of culturally relevant content and acknowledgement of health beliefs that could influence program engagement; (2) Latinas’ identities and family demands could interfere with engagement. Communication strategies to engage family members and intervention delivery in family- or group-based formats were key engagement factors; and (3) low health literacy about comorbidities associated with obesity interfere with adoption and dissemination. However, community health workers were considered necessary and important for program dissemination and sustainment. This study provides additional evidence on the importance of community engagement to adapt evidence-based interventions for cultural relevance as well as implications for future research to explicitly focus on sustainment to address the health burden of obesity and binge eating disorder.</p>