<p>Problematic social media use (PSMU) has been linked to poorer well-being, a connection that is possibly mediated by positive and negative religious/spiritual coping (PRC and NRC respectively) and limited trait mindfulness. The study aimed to explore the quantitative relationship between these variables among the general Filipino population, known for its frequent social media use yet religious nature—which may often be considered antithetical to one another. A structured survey was completed by emerging and young adults (70%) who belonged primarily to Christian religions (88%) and considered religion to be important to them (68%). The results found that mindfulness fully mediated the relationship between PSMU and well-being through NRC due to negative reinterpretation of content within religious framing. On the other hand, PRC did not mediate the relationship between social media use and well-being, unless considered with individuals who considered religion as important to them. The discussion highlights how Filipinos might draw from negative religious coping styles to deal with PSMU, affecting cognitive facilities associated with mindfulness and consequently well-being. The study provides a directional path between the variables and explores culturally relevant interventions drawing on Filipinos’ religiosity and mindful practice and discusses implications regarding psychological flexibility in the use of social media.</p>