<p>Parenting stress significantly impairs parents' quality of life, often leading to profound exhaustion in the parental role —a condition commonly referred to as parental burnout. However, the underlying mechanisms of this relation remain unexplored. The current study investigated the mediating roles of parenting stress responses and the moderating role of child-based worth in associations between parenting stressors and parental burnout, while also examining gender differences among parents and children.&#xa0;The cross-sectional study consisted of 1854 Chinese parents of children in primary and middle schools. Parenting stressors were categorized into five distinct yet interrelated domains: parenting satisfaction, parenting efforts, lack of parenting reward, lack of support, and low parenting competence. Additionally, parenting stress responses were categorized into two domains: emotional responses and physical responses. Moderated mediation models were used to examine the relations.&#xa0;Results indicated that all five parenting stressors were related to more parental burnout. Both emotional and physical responses partially mediated these associations. Additionally, high levels of child-based worth were associated with stronger links between parenting stressors and both physical responses and parental burnout, whereas low levels of child-based worth weakened these associations. No significant gender differences were found for either parents or children.&#xa0;These findings provide evidence for the associations between parenting stress and parental burnout, highlighting the need for more attention to parents with high levels of child-based worth.</p>