<p>Flight attendant safety performance is crucial to the overall safety of any airline. Although the current safety Literature has identified a number of influencing factors for safety, Little is known about the mechanisms linking safety climate to safety performance, and how organizational, group, and individual factors interact to promote the safety performance of flight attendants. Drawing on signaling theory, this study proposes a moderated mediation model to investigate the relationships among safety climate, safety attitude, coworker support, and safety performance. This is a cross-sectional design study. Using a series of anonymous questionnaires, data were collected from 614 Chinese flight attendants. The results show that safety attitude functioned as a mediating variable in the relationship between safety climate and safety performance. Furthermore, coworker support plays a moderating role in these linkages. Specifically, when flight attendants experienced more coworker support, both the relationship between safety climate and safety performance and the relationship between safety attitude and safety performance were stronger compared to when they had lower levels of coworker support. Building on these findings, theoretical and practical implications are provided for researchers and practitioners in designing interventions to promote safety performance in airlines.</p>