<p>Previous studies have shown that parental overprotection is a key family factor linked to suicide risk, and this link varies across populations (e.g., abled vs. disabled). However, few studies have examined the relationship between parental overprotection and suicide risk among deaf college students, leading to a lack of understanding of whether and how parental overprotection affects their suicide risk. This study seeks to explore the relationship between parental overprotection and suicide risk and the mediating role of perceived burdensomeness and depression among deaf college students, as well as to compare the differences between them and hearing college students. Data were collected from a sample of 217 deaf college students (50.69% female; <i>M</i>_age = 20.99, <i>SD</i> = 1.66) and a demographically Matched sample of 232 hearing college students (56.90% female; <i>M</i>_age = 20.71, <i>SD</i> = 1.73) in a university. Measures included questionnaires of parental overprotection, suicide risk, perceived burdensomeness, and depression. The results found that maternal, not paternal, overprotection was positively associated with suicide risk among deaf and hearing college students. Furthermore, perceived burdensomeness and depression mediated the influence of maternal overprotection on suicide risk. These findings enhance our understanding of how parental overprotection impacts suicide risk and the underlying mechanisms involved. Implications for prevention and intervention are discussed.</p>