<p>Insomnia is common and persistent in patients with alcohol use disorder (AUD), however, treatment of insomnia within this population remains a challenge. There is a need for careful assessment of the currently used methods to improve the effectiveness of the chosen intervention. Therefore, this study reviewed and assessed the effectiveness of the most common pharmacological and psychotherapeutic treatments on sleep quality in AUD individuals with insomnia. The databases PubMed, Scopus, Embase, Google Scholar, and PsycINFO were explored in January 2023 to find relevant research. A random effect model was used to merge the data. The difference between the pre-post mean changes of the groups (intervention vs. control) considered the effect size. The analysis included 14 studies, with 8 using pharmacological treatment. The pharmacological group showed a significantly higher mean change in sleep efficiency compared to the control group. For other sleep variables assessed, including total sleep time, sleep onset latency, wakefulness after sleep onset, and Pittsburgh Sleep Quality Index, no significant differences were observed. Similarly, the 6 studies using psychotherapeutic interventions did not show significant effects on sleep variables, except for insomnia severity. This meta-analysis demonstrates that both pharmacological and psychotherapeutic interventions are limited in their effectiveness in treating insomnia in individuals with AUD. They can improve only a few aspects of sleep quality in AUD individuals with insomnia<b>.</b> The best outcome with pharmacological intervention was obtained for sleep efficiency, whereas psychotherapeutic interventions lowered insomnia severity. However, further studies are needed to improve our understanding of this topic.</p>

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Treatment of insomnia in alcohol use disorder: a meta-analysis of pharmacological and psychotherapeutic interventions

  • Monika Gorowska,
  • Klaudia Tokarska,
  • Yonghui Li,
  • XiJing Chen

摘要

Insomnia is common and persistent in patients with alcohol use disorder (AUD), however, treatment of insomnia within this population remains a challenge. There is a need for careful assessment of the currently used methods to improve the effectiveness of the chosen intervention. Therefore, this study reviewed and assessed the effectiveness of the most common pharmacological and psychotherapeutic treatments on sleep quality in AUD individuals with insomnia. The databases PubMed, Scopus, Embase, Google Scholar, and PsycINFO were explored in January 2023 to find relevant research. A random effect model was used to merge the data. The difference between the pre-post mean changes of the groups (intervention vs. control) considered the effect size. The analysis included 14 studies, with 8 using pharmacological treatment. The pharmacological group showed a significantly higher mean change in sleep efficiency compared to the control group. For other sleep variables assessed, including total sleep time, sleep onset latency, wakefulness after sleep onset, and Pittsburgh Sleep Quality Index, no significant differences were observed. Similarly, the 6 studies using psychotherapeutic interventions did not show significant effects on sleep variables, except for insomnia severity. This meta-analysis demonstrates that both pharmacological and psychotherapeutic interventions are limited in their effectiveness in treating insomnia in individuals with AUD. They can improve only a few aspects of sleep quality in AUD individuals with insomnia. The best outcome with pharmacological intervention was obtained for sleep efficiency, whereas psychotherapeutic interventions lowered insomnia severity. However, further studies are needed to improve our understanding of this topic.