<p>Research on the contextual antecedents of creativity has predominantly focused on organizations, whereas the relationships between family contextual demands and employee creativity are far less investigated. The present study builds a moderated multiple mediation model to investigate the spillover effect of family ostracism on creativity at work via positive family–work resource spillover and creative self-efficacy and the moderating role of mindfulness. Drawing from the home–work resource model, we proposed that contextual family demands diminish limited personal resources and spill over across family–work boundaries to consume further resources. This may result in individuals not functioning optimally and influence outcomes in the workplace. We found that family ostracism was negatively and significantly related to creativity at work via positive family–work resource spillover and creative self-efficacy. Furthermore, the effects of family ostracism are more likely to be alleviated when the mindfulness is higher rather than when the mindfulness is lower. Theoretical and practical implications are discussed as are limitations and suggestions for future research.</p>