Scholarlink

<p>Insomnia inflicts physical and spiritual harm, potentially leading to depressive disorders. Insomnia has a symbiotic relationship with depression, and even could be predictive of depression, which as an early marker of it. Early detection and intervention among high risk of depression due to insomnia may promote positive individual development. Total of 865 subjects were recruited: 439 in the depression-insomnia group, 262 in the insomnia group, and 164 in the healthy group. Functional near-infrared spectroscopy(fNIRS) combined with a verbal fluency task recorded brain activation, along with depression/ anxiety/ insomnia scores. In the left dorsolateral prefrontal cortex (DLPFC), oxyhemoglobin(HbO) levels were higher in the healthy group compared to both the insomnia and depression-insomnia groups (<i>p</i> &lt; 0.01). In the right Broca’s and left orbitofrontal cortex (OFC), HbO were higher in insomnia group than in the depression-insomnia group (<i>p</i> &lt; 0.05). There was a positive correlation between depression scores, insomnia scores, and HbO in the left DLPFC (<i>p</i> &lt; 0.05). Insomnia scores showed positive correlation with HbO in the left OFC (<i>p</i> &lt; 0.05). The left OFC mediated the process from insomnia to depression, while the left DLPFC directly moderated the impact of insomnia on depression and moderated the influence of the left OFC on depression. Hemodynamic patterns in the right Broca’s and left OFC could serve as early indicators to differentiate whether insomnia population are also experiencing depression, suggesting that fNIRS could be used as a diagnostic tool. Interventions the left OFC and DLPFC in insomnia population have the potential to alleviate depressive symptoms.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The role of dorsolateral and orbitofrontal cortex in depressed with insomniacs population: a large-scale fNIRS study

  • 期刊论文

  • 发表日期：

    2025年4月2日

查看全文
  • Yan Zhang,
  • Linfei Su,
  • Hui Da,
  • Binbin Ji,
  • Qiang Xiao,
  • Hui Shi

摘要

Insomnia inflicts physical and spiritual harm, potentially leading to depressive disorders. Insomnia has a symbiotic relationship with depression, and even could be predictive of depression, which as an early marker of it. Early detection and intervention among high risk of depression due to insomnia may promote positive individual development. Total of 865 subjects were recruited: 439 in the depression-insomnia group, 262 in the insomnia group, and 164 in the healthy group. Functional near-infrared spectroscopy(fNIRS) combined with a verbal fluency task recorded brain activation, along with depression/ anxiety/ insomnia scores. In the left dorsolateral prefrontal cortex (DLPFC), oxyhemoglobin(HbO) levels were higher in the healthy group compared to both the insomnia and depression-insomnia groups (p < 0.01). In the right Broca’s and left orbitofrontal cortex (OFC), HbO were higher in insomnia group than in the depression-insomnia group (p < 0.05). There was a positive correlation between depression scores, insomnia scores, and HbO in the left DLPFC (p < 0.05). Insomnia scores showed positive correlation with HbO in the left OFC (p < 0.05). The left OFC mediated the process from insomnia to depression, while the left DLPFC directly moderated the impact of insomnia on depression and moderated the influence of the left OFC on depression. Hemodynamic patterns in the right Broca’s and left OFC could serve as early indicators to differentiate whether insomnia population are also experiencing depression, suggesting that fNIRS could be used as a diagnostic tool. Interventions the left OFC and DLPFC in insomnia population have the potential to alleviate depressive symptoms.