<p>Reproductive justice links reproductive rights with social equity, addressing barriers to marginalized women’s autonomy. Though condoms prevent sexually transmitted infections (STIs), inadequate sexual education and socio-cultural norms hinder their use. This study examines the factors affecting women’s advocacy for condom use in Ghana as a strategy for STI prevention. Using data from the 2022 Ghana Demographic and Health Survey, the study analyzed a weighted sample of 3,458 women who had sexual partners other than their spouses. Reproductive Justice was measured as women’s ability to negotiate safer sex, while socio-demographic, household, community, and empowerment factors were examined using binary logistic regression. Findings indicate that 89.6% of women supported a wife right to demand condom use if her husband has an STI, while 10.4% did not. Several factors significantly influenced women’s opinions on reproductive justice. Women from households headed by individuals aged 20–29 years (aOR = 1.77) and those residing in urban areas (aOR = 1.27) were more likely to advocate for condom use. Conversely, co-habiting women (aOR = 0.50) and those with no formal education (aOR = 0.51) were less likely to support this view. Literate women (aOR = 2.06; C.I:1.45–2.94) demonstrated higher advocacy for condom use, reinforcing the role of formal education in empowering women. However, women who jointly owned land with partners (aOR = 0.48) had lower odds of supporting condom negotiation. The study highlights the need for targeted educational programs, socio-demographic equity and community empowerment to enhance women women’s ability to negotiate safer sexual practice, ultimately promoting reproductive justice.</p>