<p>Mastery, defined as a multidimensional sense of control over life outcomes through personal agency and support from family and friends, is a potential protective factor against mental health challenges. Drawing from an online survey sample of 553 sexual minority emerging adults, this study uses a person-centered approach to explore the mastery profiles of Filipino sexual minority emerging adults and their associations with bidimensional mental health, encompassing mental well-being and psychological distress. Latent profile analysis identified four mastery profiles: <i>High Overall Mastery</i> (22.4%), <i>Moderate Overall Mastery</i> (39.4%), <i>Other-Dependent Mastery</i> (22.4%), and <i>Self-Dependent Mastery</i> (15.7%). These profiles revealed nuanced patterns of mastery sourced from the self, family, and friends. Significant differences in mental health outcomes were observed across the profiles, with <i>High Overall Mastery</i> linked to the highest mental well-being and lowest psychological distress (<i>p</i> &lt; 0.05). These findings highlight the importance of understanding the diverse configurations of mastery across ecological levels and their implications for sexuality-affirming mental health interventions.</p>