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<p>Intraductal carcinoma (IDC) of the salivary gland is an uncommon epithelial neoplasm characterized by a predominantly intraductal or intracystic proliferation rimmed by a myoepithelial cell layer. Advances in molecular profiling have revealed recurrent gene fusions in IDC, most frequently involving <i>RET</i>, although fusions implicating other kinase genes have also been described. Among these, <i>ALK</i> rearrangements are rare and remain poorly characterized. Herein, we report a case of oncocytic IDC of the parotid gland harboring a <i>STRN::ALK</i> fusion, further expanding the molecular landscape of this tumor. Although this fusion has been previously reported in intercalated duct IDC, to our knowledge, this is the first report of this specific fusion in oncocytic IDC.</p>

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Oncocytic Intraductal Carcinoma of the Parotid Gland with STRN::ALK Fusion

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月30日

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  • Reham H. Soliman,
  • Chris Shi,
  • Kevin E. Fisher,
  • Hong Yu,
  • Fouad El-Dana,
  • Xu Cao,
  • Li Liang,
  • Pei Ying,
  • Songlin Zhang

摘要

Intraductal carcinoma (IDC) of the salivary gland is an uncommon epithelial neoplasm characterized by a predominantly intraductal or intracystic proliferation rimmed by a myoepithelial cell layer. Advances in molecular profiling have revealed recurrent gene fusions in IDC, most frequently involving RET, although fusions implicating other kinase genes have also been described. Among these, ALK rearrangements are rare and remain poorly characterized. Herein, we report a case of oncocytic IDC of the parotid gland harboring a STRN::ALK fusion, further expanding the molecular landscape of this tumor. Although this fusion has been previously reported in intercalated duct IDC, to our knowledge, this is the first report of this specific fusion in oncocytic IDC.