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Purpose <p>Warthin-like mucoepidermoid carcinoma (WL-MEC) is a low-grade variant of mucoepidermoid carcinoma (MEC), characterized by a multicystic growth pattern and dense lymphoid stroma, histologically mimicking Warthin tumor (WT). Few cases have been reported, limiting understanding of this variant. We aimed to provide a comprehensive clinical, histopathologic, and molecular analysis of new WL-MEC cases.</p> Methods and Results <p>Fourteen WL-MEC cases from Brazil, Guatemala, and Mexico were analyzed. Clinicopathologic features (patient demographics, tumor location, AFIP grading, follow-up, recurrence), histological characteristics (architectural patterns, inflammatory infiltrate, epithelial components, invasion), and immunohistochemical profiles (CK5/6, p63, p40, CK7, CK14, Ki67, HER2) were assessed. <i>MAML2</i> generearrangements and <i>HER2</i> amplification were evaluated by fluorescence in situ hybridization (FISH). All 14 cases showed <i>MAML2</i> rearrangement (100%), confirming the diagnosis, while <i>HER2</i> amplification was absent in all 9 cases tested.</p> Conclusions <p>This study provides new insights into the clinicopathological and molecular features of WL-MEC, confirming its typical presentation (parotid gland, middle-aged females), low-grade behavior, and favorable prognosis after surgical excision. Detection of <i>MAML2</i> rearrangement is a valuable diagnostic tool for distinguishing WL-MEC from WT.</p>

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Characterizing Warthin-Like Mucoepidermoid Carcinoma: Clinicopathologic Features and MAML2 Rearrangements in 14 Latin American Cases

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月29日

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  • Ricardo Anderson de Oliveira Vasconcelos,
  • Isaac Santos Araújo,
  • Luiz Miguel Ferreira,
  • João Paulo Gonçalves de Paiva,
  • Igor Lima Fernandes,
  • Lucas Faria Abrahao-Machado,
  • Claudia Haydee Sarai Caro-Sánchez,
  • Ana María Cano-Valdez,
  • Adalberto Mosqueda-Taylor,
  • Ciro Dantas Soares

摘要

Purpose

Warthin-like mucoepidermoid carcinoma (WL-MEC) is a low-grade variant of mucoepidermoid carcinoma (MEC), characterized by a multicystic growth pattern and dense lymphoid stroma, histologically mimicking Warthin tumor (WT). Few cases have been reported, limiting understanding of this variant. We aimed to provide a comprehensive clinical, histopathologic, and molecular analysis of new WL-MEC cases.

Methods and Results

Fourteen WL-MEC cases from Brazil, Guatemala, and Mexico were analyzed. Clinicopathologic features (patient demographics, tumor location, AFIP grading, follow-up, recurrence), histological characteristics (architectural patterns, inflammatory infiltrate, epithelial components, invasion), and immunohistochemical profiles (CK5/6, p63, p40, CK7, CK14, Ki67, HER2) were assessed. MAML2 generearrangements and HER2 amplification were evaluated by fluorescence in situ hybridization (FISH). All 14 cases showed MAML2 rearrangement (100%), confirming the diagnosis, while HER2 amplification was absent in all 9 cases tested.

Conclusions

This study provides new insights into the clinicopathological and molecular features of WL-MEC, confirming its typical presentation (parotid gland, middle-aged females), low-grade behavior, and favorable prognosis after surgical excision. Detection of MAML2 rearrangement is a valuable diagnostic tool for distinguishing WL-MEC from WT.