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<p>High risk human papillomavirus (HR-HPV) has been a well-documented etiology of oropharyngeal malignancy. Recently, the sinonasal tract has been recognized as a second “hot spot” in the head and neck region for HPV associated tumors. Most HR-HPV associated tumors in the sinonasal tract are squamous cell carcinomas. High-grade non-intestinal type sinonasal adenocarcinoma (NITAC) is a rare malignant neoplasm that, to our knowledge, has been convincingly reported just once previously in association with HR-HPV. We report a new case of high grade NITAC associated with HR-HPV in a 64-year-old male patient, along with a literature review emphasizing differential diagnoses and potential clinical implications.</p>

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High-Risk HPV-Positive Sinonasal Adenocarcinoma: A Case Report and Review of Literature

  • 期刊论文

  • 发表日期：

    2025年9月22日

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  • Claire A. Krasinski,
  • Anuj Verma,
  • Sanhong Yu,
  • Alexander Ladenheim

摘要

High risk human papillomavirus (HR-HPV) has been a well-documented etiology of oropharyngeal malignancy. Recently, the sinonasal tract has been recognized as a second “hot spot” in the head and neck region for HPV associated tumors. Most HR-HPV associated tumors in the sinonasal tract are squamous cell carcinomas. High-grade non-intestinal type sinonasal adenocarcinoma (NITAC) is a rare malignant neoplasm that, to our knowledge, has been convincingly reported just once previously in association with HR-HPV. We report a new case of high grade NITAC associated with HR-HPV in a 64-year-old male patient, along with a literature review emphasizing differential diagnoses and potential clinical implications.