<p>We describe the novel occurrence of a adenocarcinoma involving the trachea, with distinct solid and glandular components, in a 34-year-old patient. We illustrate its morphological and immunophenotypic features and describe the molecular finding of an EWSR1::BEND2 gene fusion detected by next-generation sequencing (NGS). We discuss the findings in comparison to BEND2-fusion associated neoplasms reported in the head and neck region in the literature to date.</p>

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EWSR1::BEND2 Adenocarcinoma with Hyaline Pseudorosettes of the Trachea

  • Juan J. Sanchez-Ramirez,
  • Matthew R. Hoffman,
  • John C. Keech,
  • Anthony N. Snow,
  • Andrew M. Bellizzi,
  • Anand Rajan

摘要

We describe the novel occurrence of a adenocarcinoma involving the trachea, with distinct solid and glandular components, in a 34-year-old patient. We illustrate its morphological and immunophenotypic features and describe the molecular finding of an EWSR1::BEND2 gene fusion detected by next-generation sequencing (NGS). We discuss the findings in comparison to BEND2-fusion associated neoplasms reported in the head and neck region in the literature to date.