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<p>Protein Tyrosine Phosphatase Non-receptor type 22 (PTPN22) is a tyrosine-phosphatase that plays a major role in inhibiting T-cell activation in immune cells. Recent studies have revealed that downregulation of PTPN22 triggers T-cell activation and enhances antitumor immune response, thereby identifying PTPN22 as a potential pharmacological target in cancer-immunology.</p><p>Here we report the <sup>1</sup>H, <sup>15</sup>N and <sup>13</sup>C backbone resonance assignment for the 35.6&#xa0;kDa catalytic domain of human&#xa0;PTPN22. This assignment will provide an essential experimental tool to identify and characterize potential PTPN22 inhibitors.</p>

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1H, 13C and 15N backbone resonance assignment of the catalytic domain of human PTPN22

  • 期刊论文

  • 发表日期：

    2025年4月25日

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  • Bryan T. Martin,
  • Michael W. Clarkson,
  • Ping Wu,
  • Paola Di Lello

摘要

Protein Tyrosine Phosphatase Non-receptor type 22 (PTPN22) is a tyrosine-phosphatase that plays a major role in inhibiting T-cell activation in immune cells. Recent studies have revealed that downregulation of PTPN22 triggers T-cell activation and enhances antitumor immune response, thereby identifying PTPN22 as a potential pharmacological target in cancer-immunology.

Here we report the 1H, 15N and 13C backbone resonance assignment for the 35.6 kDa catalytic domain of human PTPN22. This assignment will provide an essential experimental tool to identify and characterize potential PTPN22 inhibitors.