<p>This study tested the effect of COVID-19 restrictions on calls for service related to drugs, alcohol, and mental health. The calls for service regarding these outcomes before, during, and after COVID-19 restrictions were aggregated into daily counts (N = 3,213). Two different measures, including count and rate, were used for these outcomes. The results of the multivariate analyses, which included negative binomial regression for the count measures, ordinary least squares (OLS) regression for the rate measures, and daily interrupted time series analyses, indicated that calls related to drugs and mental health significantly increased during the COVID-19 restrictions. However, while alcohol-related calls also increased, this rise was not statistically significant. The limitations and implications of the study are discussed.</p>