Scholarlink

Objectives <p>To establish age-specific normal reference range for urinary calcium-to-creatinine ratio (UCa/Cr) in healthy children aged 7–12 y from urban Kolhapur.</p> Methods <p>A total of 358 children was enrolled after obtaining ethical approval and parental consent. Second-morning, non-fasting urine samples were collected in a sterile, labelled container for analysing urinary calcium by the Cresolpthalein complexone spectrophotometric method and urinary creatinine by Modified Jaffe’s method.</p> Results <p>The mean urinary calcium-to-creatinine ratio across different age groups ranged from 0.12 ± 0.08&#xa0;mg/mg at age 7 to 0.09 ± 0.02&#xa0;mg/mg at age 12 y, with the highest value observed at age 8 (0.15 ± 0.05&#xa0;mg/mg). The normal reference range for urinary calcium-to-creatinine ratio in this population was found to be 0.05 ± 0.192&#xa0;mg/mg. These findings are consistent with previous studies showing a decline in urinary calcium-to-creatinine ratio with age, likely due to hormonal changes and increased calcium absorption during puberty.</p> Conclusions <p>Establishing population-specific reference values is crucial for accurate diagnosis of hypercalciuria and related disorders in children. This study provides valuable data for clinical practice in the Kolhapur region, aiding in the early detection and management of calcium metabolism disorders in children.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Normal Reference Range of the Urinary Calcium/Creatinine Ratio in Healthy Children

  • 期刊论文

  • 发表日期：

    2026年7月10日

查看全文
  • Vaibhav D. Lokhande,
  • Vaishali S. Patil,
  • Suhas P. Kulkarni

摘要

Objectives

To establish age-specific normal reference range for urinary calcium-to-creatinine ratio (UCa/Cr) in healthy children aged 7–12 y from urban Kolhapur.

Methods

A total of 358 children was enrolled after obtaining ethical approval and parental consent. Second-morning, non-fasting urine samples were collected in a sterile, labelled container for analysing urinary calcium by the Cresolpthalein complexone spectrophotometric method and urinary creatinine by Modified Jaffe’s method.

Results

The mean urinary calcium-to-creatinine ratio across different age groups ranged from 0.12 ± 0.08 mg/mg at age 7 to 0.09 ± 0.02 mg/mg at age 12 y, with the highest value observed at age 8 (0.15 ± 0.05 mg/mg). The normal reference range for urinary calcium-to-creatinine ratio in this population was found to be 0.05 ± 0.192 mg/mg. These findings are consistent with previous studies showing a decline in urinary calcium-to-creatinine ratio with age, likely due to hormonal changes and increased calcium absorption during puberty.

Conclusions

Establishing population-specific reference values is crucial for accurate diagnosis of hypercalciuria and related disorders in children. This study provides valuable data for clinical practice in the Kolhapur region, aiding in the early detection and management of calcium metabolism disorders in children.