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Objectives <p>Globally, diarrheal diseases are a leading cause of infectious disease morbidity and mortality among children aged under 5 y. Rotavirus is a primary cause of severe diarrhea in children, and India accounts for 22% of rotavirus deaths worldwide. This study aimed to determine the prevalence and distribution of circulating rotavirus genotypes among hospitalized children aged under 5 y in Odisha, India.</p> Methods <p>This prospective hospital-based study was conducted between January and December 2023 at four tertiary care hospitals in Odisha. Stool samples were collected from enrolled children aged under 5 y admitted with acute gastroenteritis and tested for rotavirus antigen at a central laboratory using an enzyme-linked immunosorbent assay (ELISA). The ELISA-positive samples were genotyped using heminested reverse-transcription polymerase chain reaction.</p> Results <p>Of the 365 children enrolled, 288 had their stool samples tested for rotavirus. Rotavirus was confirmed in 67 (23.3%) children, and 66 samples were genotyped. The most prevalent genotypes were G2P[4] (<i>n</i> = 27, 40.9%) and G3P[8] (<i>n</i> = 22, 33.3%).</p> Conclusions <p>These findings highlight the importance of ongoing molecular surveillance to monitor the circulating rotavirus strains to inform public health strategies and future research aimed at optimizing rotavirus vaccination programs.</p>

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Genotype Distribution of Rotavirus Strains and Its Association with Severity of Diarrhea Among Children Under Five Hospitalized with Acute Gastroenteritis in Odisha, India

  • 期刊论文

  • 发表日期：

    2025年10月14日

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  • Prasantajyoti Mohanty,
  • Pravakar Mishra,
  • Subal Kumar Pradhan,
  • Rajib Kumar Ray,
  • Lipsa Roul,
  • Varsha Sudhir Chaudhary,
  • Anupama Machathi,
  • Namrata Kharat,
  • Tintu Varghese,
  • Ayyappan Vellathur Ramasamy

摘要

Objectives

Globally, diarrheal diseases are a leading cause of infectious disease morbidity and mortality among children aged under 5 y. Rotavirus is a primary cause of severe diarrhea in children, and India accounts for 22% of rotavirus deaths worldwide. This study aimed to determine the prevalence and distribution of circulating rotavirus genotypes among hospitalized children aged under 5 y in Odisha, India.

Methods

This prospective hospital-based study was conducted between January and December 2023 at four tertiary care hospitals in Odisha. Stool samples were collected from enrolled children aged under 5 y admitted with acute gastroenteritis and tested for rotavirus antigen at a central laboratory using an enzyme-linked immunosorbent assay (ELISA). The ELISA-positive samples were genotyped using heminested reverse-transcription polymerase chain reaction.

Results

Of the 365 children enrolled, 288 had their stool samples tested for rotavirus. Rotavirus was confirmed in 67 (23.3%) children, and 66 samples were genotyped. The most prevalent genotypes were G2P[4] (n = 27, 40.9%) and G3P[8] (n = 22, 33.3%).

Conclusions

These findings highlight the importance of ongoing molecular surveillance to monitor the circulating rotavirus strains to inform public health strategies and future research aimed at optimizing rotavirus vaccination programs.