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Objectives <p>In Gujarat, indigenous oral pentavalent rotavirus vaccine, ROTASIIL was introduced in July 2019; however, post marketing research on this vaccine is currently lacking. This cross-sectional study was conducted among children aged &lt; 5 y hospitalized with acute gastroenteritis in Rajkot, Gujarat with an aim to investigate the epidemiology of rotavirus gastroenteritis following rotavirus vaccine introduction in the Universal Immunization Program (UIP) of Gujarat.</p> Methods <p>Children aged &lt; 5 y admitted with acute gastroenteritis between February 2021 and December 2023 were enrolled in the study. Data were collected on sociodemographic and clinical characteristics, and a copy of the child’s vaccination card. Stool samples were collected and tested for rotavirus using an enzyme immunoassay. Rotavirus-positive samples were genotyped using reverse-transcription polymerase chain reaction.</p> Results <p>Of the 288 stool samples tested, 66 (22.9%) were rotavirus positive. The prevalence of rotavirus positivity was higher in children with five or more diarrheal episodes within 24&#xa0;h than in those with fewer episodes and higher in vaccinated than in unvaccinated children. The prevalence of rotavirus positivity was lower in those with a length of hospital stay ≥ 5 d than in those with shorter stays, and in infants aged 0–5 mo than in older children. G3P[8] (48.5%) was the most prevalent rotavirus genotype, followed by G2P[4] (37.9%).</p> Conclusions <p>Rotavirus diarrhea remains prevalent among children hospitalized with acute gastroenteritis in Rajkot. G3P[8] and G2P[4] are the predominant circulating rotavirus strains.</p>

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Epidemiology of Rotavirus Gastroenteritis and Circulating Genotypes Among Hospitalized Children Aged Under 5 Years in Rajkot, Gujarat

  • 期刊论文

  • 发表日期：

    2025年9月24日

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  • Rajesh K. Chudasama,
  • Pankaj Buch,
  • Varsha Sudhir Chaudhary,
  • Anupama Machathi,
  • Namrata Kharat,
  • Ragavi Lingam,
  • Tintu Varghese

摘要

Objectives

In Gujarat, indigenous oral pentavalent rotavirus vaccine, ROTASIIL was introduced in July 2019; however, post marketing research on this vaccine is currently lacking. This cross-sectional study was conducted among children aged < 5 y hospitalized with acute gastroenteritis in Rajkot, Gujarat with an aim to investigate the epidemiology of rotavirus gastroenteritis following rotavirus vaccine introduction in the Universal Immunization Program (UIP) of Gujarat.

Methods

Children aged < 5 y admitted with acute gastroenteritis between February 2021 and December 2023 were enrolled in the study. Data were collected on sociodemographic and clinical characteristics, and a copy of the child’s vaccination card. Stool samples were collected and tested for rotavirus using an enzyme immunoassay. Rotavirus-positive samples were genotyped using reverse-transcription polymerase chain reaction.

Results

Of the 288 stool samples tested, 66 (22.9%) were rotavirus positive. The prevalence of rotavirus positivity was higher in children with five or more diarrheal episodes within 24 h than in those with fewer episodes and higher in vaccinated than in unvaccinated children. The prevalence of rotavirus positivity was lower in those with a length of hospital stay ≥ 5 d than in those with shorter stays, and in infants aged 0–5 mo than in older children. G3P[8] (48.5%) was the most prevalent rotavirus genotype, followed by G2P[4] (37.9%).

Conclusions

Rotavirus diarrhea remains prevalent among children hospitalized with acute gastroenteritis in Rajkot. G3P[8] and G2P[4] are the predominant circulating rotavirus strains.