Scholarlink

Background <p>Bacterial and fungal infections pose significant challenges in the management of patients with haematological malignancies (HM), substantially affecting the impact on clinical outcomes, including prolonged hospitalization and reduced life expectancy. Increased susceptibility to bacterial and/or fungal pathogens can occur due to immunosuppression, either inherent to the haematological disorder or induced by specific therapeutic strategies.</p> Methods <p>In this study, we quantified the plasma levels of four cytokines (interferon-γ, interleukin-5, interleukin-17, and transforming growth factor-β) in a cohort of 75 adult HM patients who developed bacterial and/or fungal infections, using a newly modified enzyme-linked immunosorbent assay platform.</p> Results <p>We observed significant changes in the plasma cytokine levels at the infection onset. The median concentration levels of T helper 1 (IFN-γ), T helper 2 (IL-5), and T helper 17 (IL-17) cytokines were significantly higher as compared to those during pre-infection and post-infection (<i>P</i> &lt; 0.05). In contrast, the level of regulatory T cells (TGF-β) exhibited a significant decrease at the time of infection compared to the pre-infection time point (<i>P</i> &lt; 0.05). Further analysis revealed an imbalance in cytokine ratios, including Th1/Th2, Th1/Th17, Th1/Treg, Th2/Th17, and Th2/Treg, at the onset of infection, with increased Th1 and Th2-associated cytokines dominating these ratios.</p> Conclusion <p>Our results highlighted significant changes in the expression levels of several cytokines at the infection onset of HM patients, reflecting a strong correlation between the inflammatory state and cytokine expression, characterised by a predominance of Th1 and Th2-associated cytokines.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Comparison of plasma cytokine expression in adult haematological malignancy patients with bacterial and/or fungal infections

  • 期刊论文

  • 发表日期：

    2026年3月23日

查看全文
  • Najihah Hussein,
  • Gin Gin Gan,
  • Rukumani Devi Velayuthan,
  • Samudi Raju Chandramathi,
  • Thevambiga Iyadorai,
  • Chin Sum Cheong,
  • Chee Chiat Liong,
  • Sun Tee Tay

摘要

Background

Bacterial and fungal infections pose significant challenges in the management of patients with haematological malignancies (HM), substantially affecting the impact on clinical outcomes, including prolonged hospitalization and reduced life expectancy. Increased susceptibility to bacterial and/or fungal pathogens can occur due to immunosuppression, either inherent to the haematological disorder or induced by specific therapeutic strategies.

Methods

In this study, we quantified the plasma levels of four cytokines (interferon-γ, interleukin-5, interleukin-17, and transforming growth factor-β) in a cohort of 75 adult HM patients who developed bacterial and/or fungal infections, using a newly modified enzyme-linked immunosorbent assay platform.

Results

We observed significant changes in the plasma cytokine levels at the infection onset. The median concentration levels of T helper 1 (IFN-γ), T helper 2 (IL-5), and T helper 17 (IL-17) cytokines were significantly higher as compared to those during pre-infection and post-infection (P < 0.05). In contrast, the level of regulatory T cells (TGF-β) exhibited a significant decrease at the time of infection compared to the pre-infection time point (P < 0.05). Further analysis revealed an imbalance in cytokine ratios, including Th1/Th2, Th1/Th17, Th1/Treg, Th2/Th17, and Th2/Treg, at the onset of infection, with increased Th1 and Th2-associated cytokines dominating these ratios.

Conclusion

Our results highlighted significant changes in the expression levels of several cytokines at the infection onset of HM patients, reflecting a strong correlation between the inflammatory state and cytokine expression, characterised by a predominance of Th1 and Th2-associated cytokines.