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<p>Anal cancer is rare but increasingly common, currently accounting for 2% of all digestive neoplasms. Some 50% of anal cancers are diagnosed at the localized stage, 29% as locoregional disease, and 12% as metastatic disease. When clinical suspicion of anal cancer exists, histological confirmation, correct local staging with MRI and distant staging with thoraco-abdominal CT, and management by a multidisciplinary team are mandatory. Chemoradiotherapy with 5-FU and mitomycin C (MMC) is the standard of care for early and locally advanced disease, while combination chemotherapy with a platinum-containing compound and taxanes is the treatment of choice for metastatic disease.</p>

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SEOM–GEMCAD–TTD clinical guidelines for anal cancer (2025)

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月7日

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  • Mónica Guillot Morales,
  • Ana Fernández Montes,
  • Julen Fernández-Plana,
  • Ismael Ghanem Cañete,
  • Mireia Gil Raga,
  • Jerónimo Jiménez-Castro,
  • Ignacio Juez Martel,
  • Joan Maurel Santasusana,
  • Eduardo Polo Marqués,
  • Ma Auxiliadora Gómez-España

摘要

Anal cancer is rare but increasingly common, currently accounting for 2% of all digestive neoplasms. Some 50% of anal cancers are diagnosed at the localized stage, 29% as locoregional disease, and 12% as metastatic disease. When clinical suspicion of anal cancer exists, histological confirmation, correct local staging with MRI and distant staging with thoraco-abdominal CT, and management by a multidisciplinary team are mandatory. Chemoradiotherapy with 5-FU and mitomycin C (MMC) is the standard of care for early and locally advanced disease, while combination chemotherapy with a platinum-containing compound and taxanes is the treatment of choice for metastatic disease.