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Background <p>Due to the challenges of identifying patients with hereditary cancer predispositions in oncology practice, we propose a comprehensive and practical tool intended for oncologists managing adult patients with malignant solid tumors and/or gastrointestinal polyps.</p> Methods <p>This tool was developed based on a comprehensive review of international guidelines, GeneReviews, and recent literature. Key criteria for genetic referral were compiled and organized by organ site and tumor subtype.</p> Results <p>The resulting resource includes a primary reference table for genetic referral, a polyposis-specific table, two visual summary figures and curated lists of associated genes and syndromes to streamline the clinical decision-making process.</p> Conclusions <p>This comprehensive tool aims to support oncologists in the timely identification of patients eligible for genetic counseling, thereby enhancing therapeutic decisions and improving familial risk assessment.</p>

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Inherited cancer syndromes in adult oncology: a referral guide based on malignant tumor and polyp features

  • 期刊论文

  • 发表日期：

    2026年2月11日

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  • Audrey Guilmot,
  • Magali Belpaire,
  • Eric Olinger,
  • Anne De Leener,
  • Kevin Punie,
  • Francois P. Duhoux

摘要

Background

Due to the challenges of identifying patients with hereditary cancer predispositions in oncology practice, we propose a comprehensive and practical tool intended for oncologists managing adult patients with malignant solid tumors and/or gastrointestinal polyps.

Methods

This tool was developed based on a comprehensive review of international guidelines, GeneReviews, and recent literature. Key criteria for genetic referral were compiled and organized by organ site and tumor subtype.

Results

The resulting resource includes a primary reference table for genetic referral, a polyposis-specific table, two visual summary figures and curated lists of associated genes and syndromes to streamline the clinical decision-making process.

Conclusions

This comprehensive tool aims to support oncologists in the timely identification of patients eligible for genetic counseling, thereby enhancing therapeutic decisions and improving familial risk assessment.