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<p>Soft-tissue sarcomas are rare, diverse malignant tumors of mesenchymal origin, requiring diagnosis and treatment by a specialized multidisciplinary team. Initial assessment includes radiology and biopsy, followed by wide surgical resection with clear margins for localized cases. Radiotherapy is recommended for large, deep, high-grade tumors or after incomplete resection, while perioperative chemotherapy may be considered for high-risk cases. In oligometastatic disease, combining local and systemic therapies is an option. Anthracycline-based chemotherapy is the first-line treatment in advanced disease, though other drugs show efficacy in certain subtypes. Given the&#xa0;limited options, enrolling in clinical trials is advised for patients needing further treatment.</p>

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SEOM-GEIS Spanish clinical guidelines for the management of soft‑tissue sarcomas (2024)

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月7日

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  • César Serrano,
  • Marta Arregui,
  • Irene Carrasco,
  • Nadia Hindi,
  • Javier Martínez-Trufero,
  • Jerónimo Martínez-García,
  • Áurea Molina,
  • Ana Paisán,
  • Raúl Sánchez,
  • María Ángeles Sala

摘要

Soft-tissue sarcomas are rare, diverse malignant tumors of mesenchymal origin, requiring diagnosis and treatment by a specialized multidisciplinary team. Initial assessment includes radiology and biopsy, followed by wide surgical resection with clear margins for localized cases. Radiotherapy is recommended for large, deep, high-grade tumors or after incomplete resection, while perioperative chemotherapy may be considered for high-risk cases. In oligometastatic disease, combining local and systemic therapies is an option. Anthracycline-based chemotherapy is the first-line treatment in advanced disease, though other drugs show efficacy in certain subtypes. Given the limited options, enrolling in clinical trials is advised for patients needing further treatment.