Chronological pattern of venous thromboembolism (VTE) occurrence impacts in survival of pancreatic ductal adenocarcinoma (PDAC)

期刊论文
发表日期：

2024年4月1日

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Irene González Caraballo,
Rocío Martín Lozano,
Roberto Jiménez Rodríguez,
Javier Soto Alsar,
Laura Ortega Morán,
Miguel Martín Jiménez,
Andrés J. Muñoz Martín

摘要

Background

Limited data exist on the prognostic significance of the chronology of VTE in patients with PDAC.

Methods

Medical data and survival characteristics of patients treated for PDAC from 2019 to 2021 were retrospectively reviewed. Early VTE was defined as occurring within the three months of PDAC diagnosis.

Results

197 patients were included, 54 (27.4%) developed a VTE. Early appearance of VTE was associated with worse prognosis: median overall survival (mOS) VTE < 3 months 8.5 months (HR 1.65, 95% CI 1.11–2.46; p = 0.014), mOS VTE > 3 months 12.8 months (HR 0.78, 95% CI 0.39–1.54; p = 0.5) and mOS patients without VTE 11.4 months (95% CI 10.1–15.4). There was no significant association between the patient’s VTE risk according to the Khorana risk score (KRS) (chi2 test p-value = 0.9).

Conclusion

Early VTE is a prognostic factor in PDAC, which may identify a more aggressive subtype.