<p>The conservation of ambient-sensitive pharmaceutical drugs is critical for maintaining their efficacy and safety, yet proper storage often becomes challenging once drugs reach patients’ homes. This paper presents a patient-centric drug quality conservation monitoring system that integrates IoT and blockchain technologies to address this gap. Sensor-equipped devices continuously track environmental parameters such as temperature, humidity, light, and movement, providing real-time alerts for any deviations that may compromise drug integrity. Patients are empowered to take corrective actions regarding conservation when necessary, while blockchain technology certifies their acknowledgment of non-consumable drugs, ensuring transparency and accountability. By leveraging cryptographic sensors and Ethereum-based smart contracts, the proposed platform offers an end-to-end solution to enhance patient engagement, ensure proper drug conservation, and support healthcare providers in remote monitoring. The protocol’s performance is evaluated in terms of cost, demonstrating its feasibility as an efficient and reliable solution for drug conservation monitoring.</p>