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<p>Autoimmune hepatitis (AIH) in children presents significant diagnostic and therapeutic challenges requiring a multidisciplinary and evidence-based approach. The Indian Society of Pediatric Gastroenterology, Hepatology, and Nutrition (ISPGHAN) convened a consensus meeting on February 23, 2025, bringing together national and international experts to address key clinical and research questions. The deliberations spanned epidemiology, clinical presentation, diagnosis including autoantibodies, immunoglobulin G (IgG), histology and diagnostic scores, therapeutic strategies, management of difficult-to-treat AIH, long-term monitoring, and special scenarios, such as seronegative AIH (SN-AIH), autoimmune sclerosing cholangitis/overlap syndromes and post-transplant complications like recurrence and de novo-AIH. Recommendations were formulated using standard GRADE system and finalized through structured consensus. These guidelines aim to standardize care, assist clinicians in decision-making, and improve outcomes in children with AIH across diverse healthcare settings.</p>

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Autoimmune hepatitis in children: Guidelines of the Indian Society of Pediatric Gastroenterology, Hepatology, and Nutrition (ISPGHAN)

  • 期刊论文

  • 发表日期：

    2025年11月20日

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  • Rajeev Khanna,
  • Bikrant Bihari Lal,
  • Vikrant Sood,
  • Seema Alam,
  • Aabha Nagral,
  • Aathira Ravindranath,
  • Aditi Kumar,
  • Aniket Deshmukh,
  • Anoop Saraya,
  • Anshu Srivastava,
  • Anupam Sibal,
  • Archana Rastogi,
  • Arjun Maria,
  • Arul Premanand Lionel,
  • Ashok Choudhury,
  • A. Ashritha,
  • Bhaswati C. Acharyya,
  • Cara L. Mack,
  • Durga Prasad,
  • Geetha S. Mammayil,
  • Ishaq Malik,
  • Jagadeesh Menon,
  • Jayendra Seetharaman,
  • John Matthai,
  • Kalpana Panda,
  • Karunesh Kumar,
  • Lalit Bharadia,
  • Marion Aw,
  • Malathi Sathiyasekaran,
  • Marianne Samyn,
  • Maya Peethambaran,
  • Moinak Sen Sarma,
  • Nagendra Kumar,
  • Nanda Kerkar,
  • Nirmala Dheivamani,
  • Parijat Ram Tripathi,
  • Piyush Upadhyay,
  • Prabhsaran Kaur,
  • Prasanth K. Sobhan,
  • Rakhi Maiwall,
  • R. Bhanu Vikraman Pillai,
  • Sadhna Lal,
  • Sakshi Karkra,
  • Shivani Deswal,
  • Snehavardhan Pandey,
  • Somashekara Hosaagrahara Ramakrishna,
  • Srikanth P. Kadyada,
  • Srinivas Sankaranarayanan,
  • Surender Kumar Yachha,
  • Sumathi Bavanandam,
  • Sumit Kumar Singh,
  • Vaibhav Shah,
  • Vibhor Borkar,
  • Vikas Jain,
  • Vipul Gautam,
  • Viswanathan M. Sivaramakrishnan,
  • Shiv Kumar Sarin

摘要

Autoimmune hepatitis (AIH) in children presents significant diagnostic and therapeutic challenges requiring a multidisciplinary and evidence-based approach. The Indian Society of Pediatric Gastroenterology, Hepatology, and Nutrition (ISPGHAN) convened a consensus meeting on February 23, 2025, bringing together national and international experts to address key clinical and research questions. The deliberations spanned epidemiology, clinical presentation, diagnosis including autoantibodies, immunoglobulin G (IgG), histology and diagnostic scores, therapeutic strategies, management of difficult-to-treat AIH, long-term monitoring, and special scenarios, such as seronegative AIH (SN-AIH), autoimmune sclerosing cholangitis/overlap syndromes and post-transplant complications like recurrence and de novo-AIH. Recommendations were formulated using standard GRADE system and finalized through structured consensus. These guidelines aim to standardize care, assist clinicians in decision-making, and improve outcomes in children with AIH across diverse healthcare settings.