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<p>The primary aim of this study was to compare two lipid-related surrogate markers of insulin resistance, namely the triglyceride–glucose index and the triglyceride-to-high-density lipoprotein cholesterol ratio, between adults with Bell’s palsy and age- and sex-comparable controls. The secondary objectives were to compare individual fasting lipid and glucose parameters and to examine the relationships of these indices with routinely available inflammatory markers and vitamin D levels.&#xa0;In this single-centre, hospital-based retrospective analytical case–control study, outpatient records from a 1-year period were reviewed. Adults aged 18–45 years with Bell’s palsy and available fasting laboratory data were included and compared with age- and sex-comparable control subjects. All patients with Bell’s palsy were examined by the same otolaryngologist at presentation. The triglyceride–glucose index and triglyceride-to-high-density lipoprotein cholesterol ratio were calculated from routinely obtained fasting glucose and lipid parameters. Secondary analyses included individual metabolic variables, vitamin D, and routinely available inflammatory markers.&#xa0;A total of 100 participants were analysed, including 50 patients with Bell’s palsy and 50 controls. Both indices were higher in the Bell’s palsy group, driven by higher triglycerides and fasting glucose; HDL cholesterol was similar. Most inflammatory markers did not differ, although the neutrophil-to-lymphocyte ratio was modestly higher in patients with Bell’s palsy. Vitamin D levels tended to be lower in the Bell’s palsy group, although this difference did not reach statistical significance.&#xa0;Adults with Bell’s palsy showed higher lipid-derived insulin resistance indices at presentation. However, these findings should be interpreted as preliminary and associative because important metabolic and lifestyle confounders could not be fully controlled. These indices should not be considered diagnostic or prognostic markers, but may provide contextual information regarding possible subclinical metabolic risk. Prospective studies with structured metabolic phenotyping, adjustment for lifestyle and metabolic confounders, facial grading, and follow-up are needed.</p>

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Triglyceride–Glucose Index and TG/HDL Ratio in Adults with Bell’s Palsy: A Single-Centre Retrospective Case–Control Study

  • 期刊论文

  • 发表日期：

    2026年7月9日

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  • Serhan Keskin

摘要

The primary aim of this study was to compare two lipid-related surrogate markers of insulin resistance, namely the triglyceride–glucose index and the triglyceride-to-high-density lipoprotein cholesterol ratio, between adults with Bell’s palsy and age- and sex-comparable controls. The secondary objectives were to compare individual fasting lipid and glucose parameters and to examine the relationships of these indices with routinely available inflammatory markers and vitamin D levels. In this single-centre, hospital-based retrospective analytical case–control study, outpatient records from a 1-year period were reviewed. Adults aged 18–45 years with Bell’s palsy and available fasting laboratory data were included and compared with age- and sex-comparable control subjects. All patients with Bell’s palsy were examined by the same otolaryngologist at presentation. The triglyceride–glucose index and triglyceride-to-high-density lipoprotein cholesterol ratio were calculated from routinely obtained fasting glucose and lipid parameters. Secondary analyses included individual metabolic variables, vitamin D, and routinely available inflammatory markers. A total of 100 participants were analysed, including 50 patients with Bell’s palsy and 50 controls. Both indices were higher in the Bell’s palsy group, driven by higher triglycerides and fasting glucose; HDL cholesterol was similar. Most inflammatory markers did not differ, although the neutrophil-to-lymphocyte ratio was modestly higher in patients with Bell’s palsy. Vitamin D levels tended to be lower in the Bell’s palsy group, although this difference did not reach statistical significance. Adults with Bell’s palsy showed higher lipid-derived insulin resistance indices at presentation. However, these findings should be interpreted as preliminary and associative because important metabolic and lifestyle confounders could not be fully controlled. These indices should not be considered diagnostic or prognostic markers, but may provide contextual information regarding possible subclinical metabolic risk. Prospective studies with structured metabolic phenotyping, adjustment for lifestyle and metabolic confounders, facial grading, and follow-up are needed.