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<p>Hypopharyngeal and esophageal webs are thin membranous structures causing dysphagia and are strongly associated with iron deficiency anemia. This case series describes the clinical presentation, hematological findings, anatomical distribution, and histopathological features of webs in patients managed at a tertiary care centre, including one case of incidental squamous cell carcinoma. A retrospective analysis of ten patients diagnosed with esophageal or hypopharyngeal webs between April 2024 and July 2025 was conducted. Parameters recorded included demographics, hemoglobin levels, web location (in centimetres from the incisors), histopathological findings, and intraoperative findings. The cohort comprised eight females and two males (female-to-male ratio 4:1), with a mean age of 41.6 years (range 19–75 years). Mean hemoglobin was 9.31&#xa0;g/dL; all ten patients (100%) were anemic by WHO criteria. Web location ranged from 15 to 17&#xa0;cm from the incisors (mean 16&#xa0;cm). Four patients had hypopharyngeal webs, and one patient (a 75-year-old male, Case 7) had dual strictures with histopathology confirming squamous cell carcinoma (SCC), representing the sole malignancy in the series. Esophageal and hypopharyngeal webs predominantly affect middle-aged females and are strongly associated with iron deficiency anemia. They may serve as a premalignant condition. Early recognition, endoscopic management, iron supplementation, and histopathological evaluation are essential for optimal outcomes and timely detection of malignant transformation.</p>

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Esophageal and Hypopharyngeal Webs: A Retrospective Case Series of Ten Patients from a Tertiary Care Centre in South India

  • 期刊论文

  • 发表日期：

    2026年6月30日

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  • Saaketh Boddupalli,
  • Sharulatha Raguraman

摘要

Hypopharyngeal and esophageal webs are thin membranous structures causing dysphagia and are strongly associated with iron deficiency anemia. This case series describes the clinical presentation, hematological findings, anatomical distribution, and histopathological features of webs in patients managed at a tertiary care centre, including one case of incidental squamous cell carcinoma. A retrospective analysis of ten patients diagnosed with esophageal or hypopharyngeal webs between April 2024 and July 2025 was conducted. Parameters recorded included demographics, hemoglobin levels, web location (in centimetres from the incisors), histopathological findings, and intraoperative findings. The cohort comprised eight females and two males (female-to-male ratio 4:1), with a mean age of 41.6 years (range 19–75 years). Mean hemoglobin was 9.31 g/dL; all ten patients (100%) were anemic by WHO criteria. Web location ranged from 15 to 17 cm from the incisors (mean 16 cm). Four patients had hypopharyngeal webs, and one patient (a 75-year-old male, Case 7) had dual strictures with histopathology confirming squamous cell carcinoma (SCC), representing the sole malignancy in the series. Esophageal and hypopharyngeal webs predominantly affect middle-aged females and are strongly associated with iron deficiency anemia. They may serve as a premalignant condition. Early recognition, endoscopic management, iron supplementation, and histopathological evaluation are essential for optimal outcomes and timely detection of malignant transformation.