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<p>Intraductal carcinoma (IDC) is a rare malignant tumor of the salivary gland newly added to the World Health Organization classification in 2017. Here we report a rare case of apocrine type IDC arising from the parotid gland with a literature review. The patient was a 59-year-old man. Magnetic resonance imaging showed a cystic parotid tumor showing hyperintensity on T1- and T2-weighted images, and positron emission tomography with computed tomography showed mild <sup>18</sup>F-fluorodeoxyglucose accumulation in thick cyst walls. Surgery was performed in consideration of malignant parotid gland tumor. Postoperative pathological examination revealed apocrine type IDC. Postoperative radiation therapy was performed, and the patient is currently alive without cancer. IDC is classified into four subtypes based on differences in immunohistochemical staining and gene mutations. The apocrine type is different from other types in that it is characterized by negative for S100 and SOX10. Apocrine type IDC shows a similar immunostaining pattern to salivary duct carcinoma, but myoepithelial cells are present in the surrounding area. Surgical resection with negative margins is recommended for the treatment of resectable IDC. Various gene mutations, including fusion genes, have been identified in IDC, so it may be a good candidate for molecular targeted therapy.</p>

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Clinical, Imaging, and Pathological Features of Apocrine Intraductal Carcinoma of Salivary Glands: A Case Report and Literature Review

  • 期刊论文

  • 发表日期：

    2026年5月19日

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  • Saki Akita,
  • Masashi Kuroki,
  • Hiroki Kato,
  • Natsuko Suzui,
  • Ryo Kawaura,
  • Tatsuhiko Yamada,
  • Hirofumi Shibata,
  • Hiroshi Okuda,
  • Ryota Iinuma,
  • Kenichi Mori,
  • Takenori Ogawa

摘要

Intraductal carcinoma (IDC) is a rare malignant tumor of the salivary gland newly added to the World Health Organization classification in 2017. Here we report a rare case of apocrine type IDC arising from the parotid gland with a literature review. The patient was a 59-year-old man. Magnetic resonance imaging showed a cystic parotid tumor showing hyperintensity on T1- and T2-weighted images, and positron emission tomography with computed tomography showed mild 18F-fluorodeoxyglucose accumulation in thick cyst walls. Surgery was performed in consideration of malignant parotid gland tumor. Postoperative pathological examination revealed apocrine type IDC. Postoperative radiation therapy was performed, and the patient is currently alive without cancer. IDC is classified into four subtypes based on differences in immunohistochemical staining and gene mutations. The apocrine type is different from other types in that it is characterized by negative for S100 and SOX10. Apocrine type IDC shows a similar immunostaining pattern to salivary duct carcinoma, but myoepithelial cells are present in the surrounding area. Surgical resection with negative margins is recommended for the treatment of resectable IDC. Various gene mutations, including fusion genes, have been identified in IDC, so it may be a good candidate for molecular targeted therapy.