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<p>The nose and paranasal sinuses are anatomically and physiologically interconnected, making precise localization of lesion origin clinically challenging. A wide spectrum of pathologies—including allergic, inflammatory, granulomatous, benign, and malignant conditions—may present as sinonasal masses with variable involvement. This study emphasizes the importance of clinicopathological correlation and supports scrape cytology as a cost-effective preliminary diagnostic tool, especially in resource-limited settings. To correlate cytological and histopathological features of sinonasal masses. This prospective observational study was conducted over three years (April 2022–May 2025) on 55 patients presenting with sinonasal masses in the Otorhinolaryngology department. All patients underwent detailed clinical evaluation, including history-taking, general examination, anterior and posterior rhinoscopy, and diagnostic nasal endoscopy (DNE) to assess lesion characteristics. Radiological imaging (CT and MRI) was used to determine the extent and anatomical involvement. Scrape cytology was performed as an OPD-based screening procedure using a cyto-brush, with samples prepared on glass slides for cytological analysis. Biopsy specimens from the same lesions were obtained for histopathological examination, which served as the gold standard. The cytological findings were compared with histopathology, and statistical analysis was performed using SPSS and GraphPad Prism to calculate sensitivity, specificity, PPV, NPV, and overall diagnostic accuracy. Scrape cytology demonstrated a sensitivity of 82.6% in detecting sinonasal neoplastic lesions. The specificity and positive predictive value (PPV) were both 100%, indicating excellent ability to correctly identify true negative and true positive cases. The negative predictive value (NPV) was 88.9%, reflecting a high probability of correctly ruling out disease. Overall diagnostic accuracy was observed to be 92.7%. These findings highlight the strong diagnostic performance of scrape cytology as a reliable screening modality. Sinonasal masses encompass a diverse spectrum of lesions with overlapping clinical presentations, posing diagnostic challenges. Inflammatory polyps were the predominant non-neoplastic lesions, while inverted papilloma and squamous cell carcinoma were the most common benign and malignant tumors, respectively. Scrape cytology demonstrated diagnostic accuracy comparable to histopathology, underscoring its potential as a reliable screening modality pending further validation.</p>

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Accuracy of Scrape Cytology in Evaluation of Sinonasal Masses: Prospective Observational Study

  • 期刊论文

  • 发表日期：

    2026年4月25日

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  • Vaibhavi Patil,
  • Prasad Deshmukh,
  • Sagar Gaurkar,
  • Arvind Bhake,
  • Shraddha Jain,
  • Ayushi Ghoshmoulic,
  • Parindita Sarmah

摘要

The nose and paranasal sinuses are anatomically and physiologically interconnected, making precise localization of lesion origin clinically challenging. A wide spectrum of pathologies—including allergic, inflammatory, granulomatous, benign, and malignant conditions—may present as sinonasal masses with variable involvement. This study emphasizes the importance of clinicopathological correlation and supports scrape cytology as a cost-effective preliminary diagnostic tool, especially in resource-limited settings. To correlate cytological and histopathological features of sinonasal masses. This prospective observational study was conducted over three years (April 2022–May 2025) on 55 patients presenting with sinonasal masses in the Otorhinolaryngology department. All patients underwent detailed clinical evaluation, including history-taking, general examination, anterior and posterior rhinoscopy, and diagnostic nasal endoscopy (DNE) to assess lesion characteristics. Radiological imaging (CT and MRI) was used to determine the extent and anatomical involvement. Scrape cytology was performed as an OPD-based screening procedure using a cyto-brush, with samples prepared on glass slides for cytological analysis. Biopsy specimens from the same lesions were obtained for histopathological examination, which served as the gold standard. The cytological findings were compared with histopathology, and statistical analysis was performed using SPSS and GraphPad Prism to calculate sensitivity, specificity, PPV, NPV, and overall diagnostic accuracy. Scrape cytology demonstrated a sensitivity of 82.6% in detecting sinonasal neoplastic lesions. The specificity and positive predictive value (PPV) were both 100%, indicating excellent ability to correctly identify true negative and true positive cases. The negative predictive value (NPV) was 88.9%, reflecting a high probability of correctly ruling out disease. Overall diagnostic accuracy was observed to be 92.7%. These findings highlight the strong diagnostic performance of scrape cytology as a reliable screening modality. Sinonasal masses encompass a diverse spectrum of lesions with overlapping clinical presentations, posing diagnostic challenges. Inflammatory polyps were the predominant non-neoplastic lesions, while inverted papilloma and squamous cell carcinoma were the most common benign and malignant tumors, respectively. Scrape cytology demonstrated diagnostic accuracy comparable to histopathology, underscoring its potential as a reliable screening modality pending further validation.