<p>Radiotherapy <b>(</b>RT) and Chemoradiotherapy (CRT)-induced cochleotoxicity is well documented in the literature, but there is limited research about the potential effects of RT and CRT on vestibular symptoms. The present study aims to evaluate RT or CRT-induced vestibulotoxicity using the Video Head Impulse Test (vHIT) in patients with head and neck cancer (HNC).&#xa0;This is a prospective, observational study consisting of a cohort of 106 confirmed cases of HNC who were evaluated at baseline, 6 weeks, and 3 months post-RT/CRT. We used a horizontal vHIT assessment to document the vestibular changes in these individuals.&#xa0;In the present study, it was observed that in the group surgery + RT, surgery + CRT, as well as in only the CRT without surgery group, the vHIT findings from baseline versus 6 weeks and baseline versus 3 months showed that the median gain was highly significantly reduced on both sides. i.e., <i>p</i> &lt; 0.001, but it was not statistically significant when the values of vHIT were compared between 6weeks and to 3-month period. We have also compared the differences in findings in patients undergoing RT and CRT with surgery and only CRT without surgery, which shows no significant difference among these groups. The findings help us to understand that vestibular changes in patients who have undergone only RT/ CRT are observed and are non-transient, as significant changes were also observed at 3 months. Further, we could also document that surgery does not influence the vestibular changes and is an independent factor.&#xa0;We have documented longitudinal and objective findings in vestibular assessment, which is an evidence-based methodology to document the long-term potential impact of existing treatment. Both transient and long-lasting adverse effects have been documented. With our findings, we wish to generate awareness amongst oncological team members about the potential adverse effects on vestibular functions, dosage monitoring, and early diagnosis and intervention.</p>

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Evaluation of Radiotherapy/Radio-Chemotherapy Induced Vestibulotoxicity Using the Video Head Impulse Test (vHIT) in Patients with Head and Neck Cancer: A Prospective Study in Punjab

  • Vanita Sarin,
  • Arpita Chatterjee Shahi

摘要

Radiotherapy (RT) and Chemoradiotherapy (CRT)-induced cochleotoxicity is well documented in the literature, but there is limited research about the potential effects of RT and CRT on vestibular symptoms. The present study aims to evaluate RT or CRT-induced vestibulotoxicity using the Video Head Impulse Test (vHIT) in patients with head and neck cancer (HNC). This is a prospective, observational study consisting of a cohort of 106 confirmed cases of HNC who were evaluated at baseline, 6 weeks, and 3 months post-RT/CRT. We used a horizontal vHIT assessment to document the vestibular changes in these individuals. In the present study, it was observed that in the group surgery + RT, surgery + CRT, as well as in only the CRT without surgery group, the vHIT findings from baseline versus 6 weeks and baseline versus 3 months showed that the median gain was highly significantly reduced on both sides. i.e., p < 0.001, but it was not statistically significant when the values of vHIT were compared between 6weeks and to 3-month period. We have also compared the differences in findings in patients undergoing RT and CRT with surgery and only CRT without surgery, which shows no significant difference among these groups. The findings help us to understand that vestibular changes in patients who have undergone only RT/ CRT are observed and are non-transient, as significant changes were also observed at 3 months. Further, we could also document that surgery does not influence the vestibular changes and is an independent factor. We have documented longitudinal and objective findings in vestibular assessment, which is an evidence-based methodology to document the long-term potential impact of existing treatment. Both transient and long-lasting adverse effects have been documented. With our findings, we wish to generate awareness amongst oncological team members about the potential adverse effects on vestibular functions, dosage monitoring, and early diagnosis and intervention.