A case of Cavernous Sinus Thrombosis Followed by a Complicated Frontal Sinusitis, Cerebral Thrombophlebitis, and Pachymeningitis
摘要
Cavernous sinus thrombosis (CST) is a rare but potentially life-threatening complication of acute or chronic sinusitis, especially in pediatric patients. Early identification and aggressive management are crucial to prevent permanent neurological deficits or death. We present the case of an 11-year-old boy who developed CST as a complication of frontal sinusitis shortly after air travel. Case An 11-year-old male initially presented in France with rhinorrhea. He traveled to Kosovo on February 10, and shortly before landing, developed acute headache, otalgia, and vomiting. Three days later, he developed fever and worsening headache. He was evaluated by a pediatrician, diagnosed with acute otitis media, and treated with oral Augmentin. On February 16, due to persistent otalgia and suspected mastoiditis, he was referred to the ENT clinic. Examination revealed signs of left otomastoiditis and Chandler’s grade 1 orbital cellulitis. He was admitted and started on intravenous ceftriaxone and diclofenac. Paracentesis of the tympanic membrane yielded purulent discharge, and a grommet was inserted.The next day, the patient developed worsening periorbital edema, proptosis, and chemosis (Chandler’s grade 2). Lumbar puncture showed elevated protein without organisms. Antibiotic therapy was escalated to vancomycin. CT imaging demonstrated pansinusitis, left orbital cellulitis, and bilateral otomastoiditis, while MRI revealed chronic pansinusitis, acute mastoiditis, and a possible frontal lesion. Symptoms persisted despite treatment, and he was transferred to France on February 18. MRI confirmed CST, pachymeningitis, and frontal sinus empyema. Following 15 days of intensive inpatient therapy, the patient showed marked improvement and was discharged on oral antibiotics, with follow-up continuing until March 27. This case highlights the importance of recognizing early complications of sinusitis in children. Air travel may have contributed to sinus barotrauma and infection progression. Advanced imaging and multidisciplinary management were essential for diagnosis. CST is a rare but severe pediatric complication of sinusitis. Prompt imaging, timely antibiotic escalation, and coordinated care can significantly improve outcomes.