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<p>The occurrence of ipsilateral cervical micrometastases in Oral squamous cell carcinoma (OSCC) is not uncommon.However, OSCC patients with negative ipsilateral neck nodes having contralateral lymph node metastases are still rare. Clinical and histopathologic factors provide predictive information on contralateral lymph nodal recurrence (CLNR) in OSCC.This study evaluated the predictive value of the clinical-histopathologic factors potentially related to contralateral occult lymph node metastasis in OSSCand formed a rational basis for elective contralateral neck management.&#xa0;The observational study analyzed 1360 OSCC patients treated from January 2018 to September 2023 at an Indian medical university.CLNR-confirmed cases were included in the study but without ipsilateral or local recurrence. Statistical analysis was performed using SPSS v. Univariate, and multivariate analysis was performed for the predictor analysis. Survival outcomes were assessed using Kaplan-Maier analysis; <i>p</i> &lt; 0.05 was considered statistically significant.&#xa0;A total of 48 patients (3.5%) developed CLNR. Significant predictors of CLNR included composite stage (<i>P</i> &lt; 0.05), depth of invasion (<i>P</i> &lt; 0.05), and continued addiction post-treatment (<i>p</i> &lt; 0.05). Tumors located in the tongue and floor of the mouth demonstrated the highest recurrence rates (45.9%). Kaplan-Meier survival analysis revealed significantly reduced survival among patients with shorter recurrence intervals. Most CLNRs occurred within the first year post-surgery, with 50% emerging between 2 and 6 months.&#xa0;Composite state, and continued addiction are strong predictors of CLNR in lateralization OSCC. Tumors near the middle and high-risk anatomical subsites warrant close postoperative monitoring.</p>

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Factors Predicting Contralateral Neck Recurrence in Purely Lateralized Oral Cancer: An Observational Study

  • 期刊论文

  • 发表日期：

    2026年1月29日

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  • Tashbihul Azhar,
  • Naseem Akhtar,
  • Shiv Rajan,
  • Sameer Gupta,
  • Vijay Kumar,
  • Puneet Prakash,
  • Syeeda Mariam Karim

摘要

The occurrence of ipsilateral cervical micrometastases in Oral squamous cell carcinoma (OSCC) is not uncommon.However, OSCC patients with negative ipsilateral neck nodes having contralateral lymph node metastases are still rare. Clinical and histopathologic factors provide predictive information on contralateral lymph nodal recurrence (CLNR) in OSCC.This study evaluated the predictive value of the clinical-histopathologic factors potentially related to contralateral occult lymph node metastasis in OSSCand formed a rational basis for elective contralateral neck management. The observational study analyzed 1360 OSCC patients treated from January 2018 to September 2023 at an Indian medical university.CLNR-confirmed cases were included in the study but without ipsilateral or local recurrence. Statistical analysis was performed using SPSS v. Univariate, and multivariate analysis was performed for the predictor analysis. Survival outcomes were assessed using Kaplan-Maier analysis; p < 0.05 was considered statistically significant. A total of 48 patients (3.5%) developed CLNR. Significant predictors of CLNR included composite stage (P < 0.05), depth of invasion (P < 0.05), and continued addiction post-treatment (p < 0.05). Tumors located in the tongue and floor of the mouth demonstrated the highest recurrence rates (45.9%). Kaplan-Meier survival analysis revealed significantly reduced survival among patients with shorter recurrence intervals. Most CLNRs occurred within the first year post-surgery, with 50% emerging between 2 and 6 months. Composite state, and continued addiction are strong predictors of CLNR in lateralization OSCC. Tumors near the middle and high-risk anatomical subsites warrant close postoperative monitoring.