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<p>The present study investigated the association between HPV16/18 and papillary thyroid carcinoma.&#xa0;This cross-sectional study included 100 tissue samples from patients diagnosed with papillary thyroid carcinoma (PTC) who underwent thyroid surgery. The extracted DNA was subjected to polymerase chain reaction (PCR), followed by gel electrophoresis, to detect the presence of HPV16/18 DNA. Histopathological parameters such as tumor grade, stage, and subtype and also demographic data, including age and gender were recorded. HPV16/18 status was assessed via PCR analysis.&#xa0;Among the 100 participants, 88% were female and only 12% were male, highlighting a predominance of PTC in women. 51% of cases were unifocal and 49% multifocal. The highest proportion of HPV-positive cases (58%) was observed among patients aged 40–50 years, compared to only 8% in those under 30 and 15% in those over 50. Tumor staging revealed that 35% were stage I, 22% stage II, 41% stage III, and 2% stage IV. There was a statistically significant association between HPV status and tumor stage. Lymph node involvement was observed in 55% of cases. Notably, 80.4% of HPV-positive patients exhibited lymph node metastasis compared to only 22.7% of HPV-negative patients. The p-value (&lt; 0.01) indicated a significant association between HPV positivity and nodal involvement.&#xa0;Based on our findings, there was a significant association between PTC and infection with high-risk human papillomavirus types (16 and 18). This relationship appears to be particularly relevant in terms of tumor stage, lymph node metastasis, and patient age.</p>

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Association Between Papillary Thyroid Carcinoma and Human Papillomavirus (HPV) Infection (Types 16/18)

  • 期刊论文

  • 发表日期：

    2026年2月2日

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  • Vahid Zand,
  • Mohammadreza Vahidi,
  • Mohammadhossein Baradaranfar,
  • Sedighe Vaziribozorg,
  • Masoud Tajamolian,
  • Arghavan Rezvan

摘要

The present study investigated the association between HPV16/18 and papillary thyroid carcinoma. This cross-sectional study included 100 tissue samples from patients diagnosed with papillary thyroid carcinoma (PTC) who underwent thyroid surgery. The extracted DNA was subjected to polymerase chain reaction (PCR), followed by gel electrophoresis, to detect the presence of HPV16/18 DNA. Histopathological parameters such as tumor grade, stage, and subtype and also demographic data, including age and gender were recorded. HPV16/18 status was assessed via PCR analysis. Among the 100 participants, 88% were female and only 12% were male, highlighting a predominance of PTC in women. 51% of cases were unifocal and 49% multifocal. The highest proportion of HPV-positive cases (58%) was observed among patients aged 40–50 years, compared to only 8% in those under 30 and 15% in those over 50. Tumor staging revealed that 35% were stage I, 22% stage II, 41% stage III, and 2% stage IV. There was a statistically significant association between HPV status and tumor stage. Lymph node involvement was observed in 55% of cases. Notably, 80.4% of HPV-positive patients exhibited lymph node metastasis compared to only 22.7% of HPV-negative patients. The p-value (< 0.01) indicated a significant association between HPV positivity and nodal involvement. Based on our findings, there was a significant association between PTC and infection with high-risk human papillomavirus types (16 and 18). This relationship appears to be particularly relevant in terms of tumor stage, lymph node metastasis, and patient age.