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<p>This study aimed to investigate the relationship between non-invasive fungal rhinosinusitis, serum albumin levels, and the recurrence rate following treatment. In this case-control study 50 patients with AFRS and 50 controls with other ENT conditions were included. Diagnosis of AFRS was based on clinical examination, diagnostic nasal endoscopy, and CT imaging. Preoperative serum albumin levels were measured. Patients underwent endoscopic sinus surgery. Postoperatively, patients received standard medical therapy. All patients were followed clinically 6 months postoperatively. Confirmed recurrences were recorded and the association between serum albumin and recurrence rate was assessed. The results showed a significant inverse relationship between serum albumin and the likelihood of non-invasive fungal rhinosinusitis. As albumin levels decreased, the risk of AFRS increased. Age was not a significant factor (p = 0.579). Male patients had significantly higher odds ratio of AFRS (OR = 18.52). In the 6-month follow-up, 3 of 50 AFRS patients (6%) experienced recurrence. Results revealed a significant difference in albumin levels between recurrence and non-recurrence groups (p = 0.003). This study revealed a significant inverse association between serum albumin levels and both the incidence and recurrence of AFRS.</p>

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The Relationship Between Non-Invasive Fungal Rhinosinusitis, Serum Albumin Levels and the Recurrence Rate Following Treatment

  • 期刊论文

  • 发表日期：

    2026年2月9日

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  • Mojtaba Meybodian,
  • Mohammad Mandegari,
  • Mohammadhossein Baradaranfar,
  • Sedighe Vaziribozorg,
  • Mohammadreza Ahi,
  • Ahmadreza Kosari

摘要

This study aimed to investigate the relationship between non-invasive fungal rhinosinusitis, serum albumin levels, and the recurrence rate following treatment. In this case-control study 50 patients with AFRS and 50 controls with other ENT conditions were included. Diagnosis of AFRS was based on clinical examination, diagnostic nasal endoscopy, and CT imaging. Preoperative serum albumin levels were measured. Patients underwent endoscopic sinus surgery. Postoperatively, patients received standard medical therapy. All patients were followed clinically 6 months postoperatively. Confirmed recurrences were recorded and the association between serum albumin and recurrence rate was assessed. The results showed a significant inverse relationship between serum albumin and the likelihood of non-invasive fungal rhinosinusitis. As albumin levels decreased, the risk of AFRS increased. Age was not a significant factor (p = 0.579). Male patients had significantly higher odds ratio of AFRS (OR = 18.52). In the 6-month follow-up, 3 of 50 AFRS patients (6%) experienced recurrence. Results revealed a significant difference in albumin levels between recurrence and non-recurrence groups (p = 0.003). This study revealed a significant inverse association between serum albumin levels and both the incidence and recurrence of AFRS.