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<p>Empty Nose Syndrome (ENS) is a debilitating condition characterized by paradoxical nasal obstruction despite patent airways, often post-turbinate surgery. Emerging evidence suggests a potential association with laryngopharyngeal reflux disease (LPRD), though the mechanisms remain unclear. To investigate the prevalence of LPRD in ENS patients and analyze correlations between reflux symptoms and ENS severity. A prospective cross-sectional study of 30 ENS patients (diagnosed via ENS6Q ≥ 12) was conducted. LPRD was screened using Reflux Symptom Score-12 (RSS-12 &gt; 11). Nasal symptoms were assessed using Nasal Obstruction Symptom Evaluation (NOSE) and Sino-Nasal Outcome Tool-25 (SNOT-25). Statistical analysis included Pearson’s correlation and Mann-Whitney U tests. Among 30 ENS patients, 63.3% (<i>n</i> = 19) had probable LPRD (RSS-12 &gt; 11). RSS-12 correlated significantly with SNOT-25 (<i>r</i> = 0.58, <i>p</i> &lt; 0.001) but not NOSE scores (<i>r</i> = 0.22, <i>p</i> = 0.25). LPRD-positive patients showed higher SNOT-25 scores (25.95 vs. 20.18, <i>p</i> = 0.069). LPRD is prevalent in ENS patients and significantly associated with sinonasal symptom burden. Routine LPRD screening (e.g., RSS-12) should be integrated into ENS management, with potential therapeutic implications. Further studies should explore causal mechanisms.</p>

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Role of Laryngopharyngeal Reflux in Empty Nose Syndrome

  • 期刊论文

  • 发表日期：

    2025年12月20日

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  • U. P. Santosh,
  • Arfan Nasser,
  • Sakshi Shah

摘要

Empty Nose Syndrome (ENS) is a debilitating condition characterized by paradoxical nasal obstruction despite patent airways, often post-turbinate surgery. Emerging evidence suggests a potential association with laryngopharyngeal reflux disease (LPRD), though the mechanisms remain unclear. To investigate the prevalence of LPRD in ENS patients and analyze correlations between reflux symptoms and ENS severity. A prospective cross-sectional study of 30 ENS patients (diagnosed via ENS6Q ≥ 12) was conducted. LPRD was screened using Reflux Symptom Score-12 (RSS-12 > 11). Nasal symptoms were assessed using Nasal Obstruction Symptom Evaluation (NOSE) and Sino-Nasal Outcome Tool-25 (SNOT-25). Statistical analysis included Pearson’s correlation and Mann-Whitney U tests. Among 30 ENS patients, 63.3% (n = 19) had probable LPRD (RSS-12 > 11). RSS-12 correlated significantly with SNOT-25 (r = 0.58, p < 0.001) but not NOSE scores (r = 0.22, p = 0.25). LPRD-positive patients showed higher SNOT-25 scores (25.95 vs. 20.18, p = 0.069). LPRD is prevalent in ENS patients and significantly associated with sinonasal symptom burden. Routine LPRD screening (e.g., RSS-12) should be integrated into ENS management, with potential therapeutic implications. Further studies should explore causal mechanisms.