<p>Sinonasal clear cell carcinoma is an extremely rare malignancy, often arising from minor salivary glands. Due to its rarity and nonspecific presentation, it can mimic more common benign conditions of sinonasal region like inverted papilloma, posing a diagnostic challenge. Early recognition with radiological imaging and histopathology as well as complete surgical excision remain crucial for optimal outcomes. The rarity of clear cell carcinoma in this anatomical location presents diagnostic challenges and underscores the importance of the detailed radiological histopathological and immunohistochemical evaluation. We present a rare case of sinonasal hyalinising clear cell carcinoma masquerading as recurrent inverted papilloma, highlighting the importance of maintaining a broad differential diagnosis for sinonasal masses, especially in patients with a history of benign lesions. Early identification through histopathology and molecular studies such as EWSR1 testing is crucial for successful management.</p>

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Sinonasal Clear Cell Carcinoma Masquerading as Recurrent Inverted Papilloma

  • Akilan Alagesan,
  • J. G. Aishwarya,
  • Vinusree K. Consultant,
  • Nithya Balasubramanian,
  • Surya Ganesan,
  • Vidya Manur Narasimhamurthy,
  • Satish Nair

摘要

Sinonasal clear cell carcinoma is an extremely rare malignancy, often arising from minor salivary glands. Due to its rarity and nonspecific presentation, it can mimic more common benign conditions of sinonasal region like inverted papilloma, posing a diagnostic challenge. Early recognition with radiological imaging and histopathology as well as complete surgical excision remain crucial for optimal outcomes. The rarity of clear cell carcinoma in this anatomical location presents diagnostic challenges and underscores the importance of the detailed radiological histopathological and immunohistochemical evaluation. We present a rare case of sinonasal hyalinising clear cell carcinoma masquerading as recurrent inverted papilloma, highlighting the importance of maintaining a broad differential diagnosis for sinonasal masses, especially in patients with a history of benign lesions. Early identification through histopathology and molecular studies such as EWSR1 testing is crucial for successful management.