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<p>Early and accurate diagnosis of laryngopharyngeal malignancies remains challenging with conventional white light endoscopy. Narrow Band Imaging (NBI) enhances mucosal vascular patterns, improving detection &amp; lesion characterization of dysplastic and malignant lesions by visualization of subtle mucosal changes. To describe a practical, office-based method of performing targeted biopsies of laryngopharyngeal lesions using a flexible nasopharyngoscope equipped with a working channel under NBI guidance. The procedure is performed under topical anaesthesia, with transnasal passage of the flexible nasopharyngoscope. Lesions are inspected sequentially under white light and NBI to identify suspicious vascular patterns. Biopsies are then obtained through the working channel using forceps, without the need for general anaesthesia or operating room setup, thus avoiding blind sampling, reducing the need for general anaesthesia &amp; providing adequate tissue for histopathological confirmation. NBI assisted flexible endoscopic biopsy provides a minimally invasive, well-tolerated, cost effective &amp; precise method for early diagnosis of laryngopharyngeal malignancies, avoiding unnecessary random biopsies and improving diagnostic yield &amp; facilitates treatment planning of laryngopharyngeal malignancies.</p>

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How I Do It: Narrow Band Imaging (NBI) Guided Biopsy in Targeted Laryngopharyngeal Lesions

  • 期刊论文

  • 发表日期：

    2025年11月13日

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  • N. Manoj Kumar,
  • Ashish Rao,
  • S. Sheethal,
  • Madhushree S. Hiremath

摘要

Early and accurate diagnosis of laryngopharyngeal malignancies remains challenging with conventional white light endoscopy. Narrow Band Imaging (NBI) enhances mucosal vascular patterns, improving detection & lesion characterization of dysplastic and malignant lesions by visualization of subtle mucosal changes. To describe a practical, office-based method of performing targeted biopsies of laryngopharyngeal lesions using a flexible nasopharyngoscope equipped with a working channel under NBI guidance. The procedure is performed under topical anaesthesia, with transnasal passage of the flexible nasopharyngoscope. Lesions are inspected sequentially under white light and NBI to identify suspicious vascular patterns. Biopsies are then obtained through the working channel using forceps, without the need for general anaesthesia or operating room setup, thus avoiding blind sampling, reducing the need for general anaesthesia & providing adequate tissue for histopathological confirmation. NBI assisted flexible endoscopic biopsy provides a minimally invasive, well-tolerated, cost effective & precise method for early diagnosis of laryngopharyngeal malignancies, avoiding unnecessary random biopsies and improving diagnostic yield & facilitates treatment planning of laryngopharyngeal malignancies.