Introduction <p>Cerebrospinal fluid leaks following penetrating skull base trauma are rare but potentially life-threatening. We describe a unique case of drone-related shrapnel injury successfully managed with a staged, multidisciplinary approach.</p> Case Report <p>A 20-year-old female soldier sustained a metallic fragment penetrating the anterior skull base, with subsequent cerebrospinal fluid leak. Initial neurosurgical intervention included craniotomy, debridement, and dural repair. This was followed by endoscopic endonasal shrapnel extraction and multilayer skull base reconstruction using autologous tissue and fibrin sealant. The patient recovered fully, with no recurrence of leak or infection at follow-up.</p> Conclusion <p>This case highlights the emerging trauma mechanism of drone warfare, underscores the feasibility of endoscopic repair in a warzone setting, and addresses the clinical dilemma of early versus delayed foreign body removal. A staged, multidisciplinary approach integrating neurosurgical and endoscopic techniques can optimize outcomes in patients with drone-related skull base trauma and cerebrospinal fluid leak.</p>